浆样树突状细胞(pDC) 是一类非常重要的先天免疫细胞。在病毒感染或其它刺激下，pDC能够产生大量的I型干扰素，因此它们又被称为干扰素产生细胞。同时， 刺激后的pDC分化成为具有抗原提呈能力的树突状细胞。我们前期研究表明，肿瘤坏死因子受体家族成员CD358特异性地表达在人pDC的表面，并能调节其产生干扰素和炎性因子的能力。在本项目中，我们将继续研究CD358对pDC功能的影响及其分子机制。我们还将利用人源化小鼠模型，研究CD358对人pDC体内发育的影响。本研究有利于增进我们对pDC的深入了解，为将来开发针对于该细胞或I型干扰素的临床免疫治疗提供理论依据。

Plasmacytoid dendritic cell (pDC) represents a vital innate immune cell lineage. They produce large amounts of type I interferon (IFN-I) upon viral infection or other stimulations, so they were also called interferon producing cells. Activated pDCs mature into dendritic morphology and gain antigen presentation capacity. Our preliminary data show that tumor necrosis factor receptor (TNFR) family member, CD358 specifically expresses on the surface of pDC and regulates its production of IFN-? and inflammatory cytokines. In this application, we propose to study the role of CD358 in pDC functions and the downstream signaling pathways. Furthermore, we are going to delineate the in vivo role of CD358 in pDC development with humanized mice model. This study will expand our understanding of pDC biology, thus prompts the pDC or IFN-I related immunotherapies.