杜仲为贵州三宝之一，是中医临床上治疗高血压方剂中的常用中药。关于杜仲在病理状态下的药代动力学(Pharmacokinetic, PK) 研究尚属空白。鉴于药物主要是作用于病理状态的机体，因此开展病理状态下的PK研究更有意义。更为重要的是，我们发现杜仲的主要降压成分松脂醇二葡萄糖苷和京尼平苷酸在正常大鼠和自发性高血压大鼠（Spontaneously hypertensive rats, SHR）模型体内的PK行为存在显著差异。然而，这种差异的潜在机制不得而知，值得深入探讨。药物转运蛋白和细胞色素P450（CYP450）在药物的PK过程中起着至关重要的作用。有鉴于此，本项目旨在利用SHR模型，比较杜仲中的五个代表成分在正常大鼠和SHR模型体内的PK差异，并从药物转运蛋白以及CYP450的角度探讨杜仲代表成分PK差异的机制，以期为贵州杜仲药材的深度开发以及治疗高血压的临床应用推广奠定理论基础。

Eucommia ulmoides is one of important and famous traditional Chinese medicine in Province Guizhou, which is commonly combined with other traditional Chinese medicine to treat hypertension. However, the study on the pharmacokinetics of Eucommia ulmoides are still carried out in the pathological states. Given the major role of drugs in the pathological state, the research of pharmacokinetics in pathological state will be more meaningful. More importantly, we have found that the pharmacokinetic behavior of Pinoresinol diglucoside and geniposidic acid with the hypotensive effect contained in Eucommia ulmoides were significantly different between normal rats and spontaneously hypertensive rats (SHR). However, the underlying mechanism for this difference is unknown and it is worthy of further exploration. It’s well known that drug transporters and cytochrome P450 (CYP450) play an important role in the absorption, distribution, metabolism and excretion of drugs. Therefore, in the present study, the pharmacokinetic difference of Five hypotensive active ingredients in Eucommia ulmoides between normal rats and SHR were investigated. Then, the expression of transport proteins in the small intestine and liver of rats and the activation of CYP450 in liver of rats were carried out to investigate the mechanism of pharmacokinetic difference. At last, this study will provide the theoretical basis for the further development of Eucommia ulmoides in Province Guizhou and its clinical application in the treatment of hypertension.