纳米泡阀形变（或吞噬泡的闭合）在生命体内无处不在，它不但在细胞自噬过程发挥关键作用，在细胞发育的膜被细胞器形成中也不可或缺，但其理论研究严重滞后。我们以胃状细胞为原型，研究磁控纳米泡阀的形变理论，并将其推广到电场情形，有利于揭示细胞自噬的机制，也为生化和医学领域面临的药物靶向输运和释放的远程控制研究提供理论支撑，同时为理论生物物理开辟新的研究方向。

The deformation of polymersome nanovalve, such as the closure of the phagophore, is ubiquitous in vivo, and plays a key role in both autophagy and the development of membrane-bound organelles. The theoretical investigation of its mechanism, however, is still absent. Here, we will develop a new field of theoretical biophysics to investigate the deformation of stomatocyte magneto-nanovalve. The resulted theory, then, be expanded to the situation of electro-nanovalve, which is conducive to reveal the mechanism of autophagy. The topic also matches the emerging application in biochemical and medical fields, for example, how can the drug be remotely transported and released at the target?