催化不对称Meerwein-Ponndorf-Verley类反应研究

手性醇、氰醇、炔醇和烯丙基醇类化合物是天然产物和药物合成中重要的合成单元。羰基的催化不对称Meerwein-Ponndorf-Verley（MPV）还原、氰化、炔基化和烯丙基化反应是合成这类手性化合物有效的方法之一。该类反应具有试剂价格低廉、毒性小等优点，使反应更具实用性。然而，催化不对称MPV还原和氰化反应的报道还很少，MPV炔基化和烯丙基化反应未见不对称催化的报道。因此，发展高效不对称催化体系，实现高选择性的催化不对称MPV还原、氰化、炔基化和烯丙基化反应仍是必要和具有挑战性的。

chiral alcohols, cyanohydrins,alkynols and allyl alcohols are important building blocks in the synthesis of natural products and medical drugs.One of the most efficient methods to synthesize these compounds is the catalytic asymmetric Meerwein-Ponndorf-Verley reduction, cyanation, alkynylation and allylation of carbonyl compounds. However, there are only few catalytic systems to efficiently catalyze the MPV reduction and cyanation of carbonyl compounds, even, there is no catalytic asymmetric system reported for the MPV alkynylation or allylation of carbonyl compounds, up to now. On the other hand, these MPV type reactions have important advantages such as using less toxic and cheaper meterials,and so on, which make the reaction more practical. So, it is great important and meaningful to develop new and efficient catalytic systems for the asymmetric MPV reduction, cyanation, alkynylation and allylation of carbonyl compounds.