双哌啶骨架手性催化剂的设计合成及在不对称反应中的应用

手性配体和手性催化剂是手性催化合成领域的核心之一。双哌啶独特的含氮笼状结构，使其具备成为优秀配体或催化剂的潜力。手性中心锁定在环上的双哌啶化合物结构难以修饰且合成困难，限制了其在不对称合成领域的发展。而在双哌啶氮原子上引入手性取代基，合成简单且取代基变化多样，为发展手性双哌啶结构配体或催化剂提供了新途径。然而，到目前为止，手性信息锁定在氮原子取代基的双哌啶骨架配体或催化剂应用于不对称反应的报道极其有限，催化剂种类和反应类型均有待发展。因此，本项目拟发展新的侧链含手性中心的双哌啶骨架化合物，并将这类化合物作为配体或催化剂应用到不对称反应中。

Chiral ligands and chiral catalysts are in the central place in the catalytic asymmetric field. The bispidines with unique nitrogen-containing cage-like structure have the potential to be excellent ligands or catalysts. Modifying the structure of bispidines with a chirally core is difficult, which restricts their application in the asymmetric synthesis. Fortunately, the introduction of a chiral substitute to one of the nitrogen atoms of bispidines provides a new way for the development of chiral bispidine compounds. However, up to now, only few examples about such catalysts were reported to catalyze asymmetric reactions. Both the catalysts and asymmetric reactions need to be developed. Herein, the applicant and coworkers plan to design and synthesis new bispidines with a chiral substitute at one of the nitrogen atoms, and apply them as chiral ligands or catalysts to promote asymmetric reactions.