自身免疫疾病是由于自身免疫反应导致组织器官损伤和相应功能障碍而引起的一类病症，包括类风湿性关节炎（RA）、系统性红斑狼疮综合症（SLE）、多发性硬化症（MS）等多种疾病。由于此类病症涉及复杂的机体免疫系统，临床一直缺乏有效的治疗药物。B淋巴细胞刺激因子（BAFF）是体内B细胞功能的重要调节因子，在体内的表达水平异常与自身免疫疾病有着密切的关系。通过阻断BAFF所诱导的一系列B细胞活动来治疗自身免疫疾病，成为近年来药物研发的重要思路。本项目拟根据自身免疫疾病的发病机理，以BAFF为靶点，采用遗传密码扩充技术，设计并筛选出可诱导机体产生抗BAFF抗体的疫苗候选分子- - 含硝基的BAFF突变体，诱导抗BAFF抗体产生，从而阻断BAFF所诱导的B细胞活动，达到治疗自身免疫疾病的目的。本项目的顺利完成不仅可以为治疗AID提供有效的候选分子，也可为其他以自体蛋白为靶点的疫苗开发提供可借鉴的思路。

Autoimmune disease(AID) arises from an inapproriate immune response of the body against substances and tissues normally existed, including rheumatoid arthritis(RA), systemic lupus erythematosus(SLE), multiple sclerosis(MS) and other diseases. Because these problems invovled in complexed immune system, there has been lack of effective drug treatment in clinical. B lymphocytes stimulating factor(BAFF) is an important factor to adjust B cell function. Over expression of BAFF may have a close relationship with AIDs. In recent years, inhibition of the B cell activities induced by BAFF makes a new way to cure AIDs. This project plans to make a new vaccine targeted in BAFF, which can induce the body to produce antibodies to fight BAFF. In order to break the immune tolerance of the BAFF as the body's own proteins, nitro will be incorporated specifically into BAFF using the genetic code expansion technique. The mutant BAFF will induce the body to produce antibodies fighting the wide type BAFF, which can block the signal path through that BAFF activates B cell. This will be a certain new vaccine to cure the AIDs. This project can not only get a new drug to treat AIDs, but also support a new method to design vaccines based on body's own proteins.