在有机合成化学及元素有机化学领域中，含杂原子功能化手性硅烷的催化合成、性能与应用研究一直以来是一个具有很大挑战性的科研难题之一，特别是硅中心光学活性硅烷的合成存在着一些挑战性的手性控制难题，值得深入研究，具有广阔的研究空间与很强的科学价值。本项目中将充分利用不对称催化合成方法构建含杂原子功能化手性有机硅化合物，从催化合成方法和产物的性能研究两方面入手并进一步研究其构效关系及基本反应性能。同时将新型功能化手性硅烷作为催化剂或试剂应用于催化合成具有应用价值的手性物质中，开发出具有高选择性手性诱导或硅－碳手性传递能力的新型含杂原子功能化有机硅化合物。研究过程中有力地结合多种表征手段与理论化学模拟技术研究有机催化反应的机理及手性诱导、转移或传递过程中可能存在的各种效应，期望在有机化学基础理论与手性合成应用上取得有特色的突破点，在硅元素资源利用化学及新物质创造方面提供重要的科学依据。

The synthesis of functional heteroatom-containing organosilicon compounds including silicon-stereogenic silanes is undoubtedly one of the most intriguing and challenging aspects in organic chemistry, asymmetric catalysis, chiral synthesis, and organosilicon chemistry. To some extent, the physical and chemical properties of silicon-stereogenic silanes are still unclear, and it is neglected by chemists in the past decades. Therefore it need to be considered as an important and urgent topic/project in asymmetric synthesis and organosilicon chemistry at present. In this project, we plan to synthesize functional heteroatom-containing organosilicon compounds and silicon-stereogenic silanes by chiral catalysts, and then study its physical, chemical properties and synthetic applications of functional organosilicon in organic reactions. The synthesis and synthetic application of functional heteroatom-containing silicon-stereogenic silanes would be one of the most significant task in this project. As another important topic, we will continue to design and prepare useful functional chiral silicon-based compounds that could be used as a novel catalyst or reagent with the ability of enantioselective induction or silicon-carbon chirality-tranfer for asymmetric synthesis. Importantly,the mechanism of related chiral silicon-mediated organic transformation by spectroscopic analysis would be important for the construction and synthetical use of functional organosilicon compounds. We believe that this project will contribute greatly to the development of organic synthetic chemistry and would be important in the chemical ultilization of silicon-based source and new material.