多组分反应制备生物医用纳米材料

载药纳米材料的可控制备是抗肿瘤药物纳米剂型临床转化的关键基本问题。本项目拟通过多组分反应，来发展生物医用功能纳米材料的合成新方法，在此基础上探索载药纳米材料的抗肿瘤性能及临床应用前景。基于Ugi和Passerini多组分反应，以含氨基的硅球、多孔配位聚合物和PLGA纳米材料作为模型纳米材料，一步合成整合药物，染料和生物相容性好的聚乙二醇到纳米材料上，获得具有治疗和成像等多功能的生物医用纳米材料。通过合理设计，优化反应条件，实现载药多功能纳米材料的高效制备，并探讨其抗肿瘤性能及系统毒性等。本项目的开展将为功能纳米材料的制备与应用提供新的方法和思路，将进一步促进合成化学与纳米医学研究的交叉融合。

The controllable preparation of drug-loaded nanomaterials is a key basic problem in the clinical transformation of anti-tumor drug nano-dosages. This project intends to develop a new synthetic method of biomedical functional nanomaterials through multi-component reaction. On this basis, the anti-tumor properties and clinical application prospects of drug-loaded nanomaterials are explored. Based on Ugi and Passerini multi-component reactions, using amino-bearing silicon spheres, porous coordination polymers and PLGA nanomaterials as model nanomaterials, one-step synthesis of integrating drugs, dyes and biocompatible polyethylene glycols to nanomaterials with versatility such as treatment and imaging. Through rational design and optimization of reaction conditions, high-efficiency preparation of drug-loaded multifunctional nanomaterials is realized, and its anti-tumor performance and system toxicity are discussed. The development of this project will provide new methods and ideas for the preparation and application of functional nanomaterials, which will further promote the cross-fusion of synthetic chemistry and nanomedicine research.