脂质体和聚合物囊泡是目前人造红血球的主要载体形式，但都暴露出一些关键的问题。本项目提出通过构建生物可降解的两亲性多臂聚合物形成的囊泡及对血红蛋白的包裹作为红血球替代物。通过合成低分散度的聚酯链段和高效的点击化学等手段，获得长度不同且精确控制的双亲性多臂聚合物组装单元，不仅有利于研究结构和性能的关系，而且便于提高组装体的均匀性和重现性。通过控制多臂聚合物的分散度、亲疏水比例和臂数来研究形成囊泡的大小及囊泡对血红蛋白包裹的效率。树枝状多臂聚合物囊泡颗粒可以增加包裹血红蛋白含量，特别是在高的聚合物浓度条件下，囊泡仍保持较低的粘度和很好流动性，有望开发出接近人血性能的红血球替代物，同时为担载水溶性药物提供新的方法。

Liposomes and polymersomes are the main carrier in the form of artificial red blood cells, but there are a number of key issues exposed. In present project, we propose to construct dendrosomes based on a biodegradable amphiphilic multi-arm polymer and encapsulation of the hemoglobin as a red blood cell substitutes. By means of the synthesis of low polydispersity polyester chains and efficient click chemistry, we will made different length and precise control of amphiphilic multi-arm polymer assembly unit, which not only conducive to study the relationship of structure and performance, and also improve the uniformity and reproducibility of dendrosomes. By control polydispersity of multi-arm polymer, the proportion of hydrophilic and hydrophobic, and the number of arms, we could study the size of dendrosomes and efficiency of vesicles to encapsulate hemoglobin. The dendritic multi-arm polymer vesicle particles can increase the content of encapsulating hemoglobin, and especially keep the vesicles with low viscosity and good fluidity under conditions of high polymer concentration. It is expected to develop red blood cell substitute close to the human blood properties and provide a new method for encapsulating water-soluble drugs at the same time.