铜催化的炔烃与叠氮的环加成反应 (CuAAC) 和氮、氧芳基化反应最近倍受关注。铜离子以不同的价态和配位结构对催化过程和结果实施有效的调控。为此，我们提出了对铜的双核、多核或螯合络合物介导的碳-氮和碳-氧键的生成反应及其应用的研究。 使用炔铜多核高聚配合物为原料，利用其 Cu-C(sp) 键的化学惰性，高度选择性地与叠氮经环加成反应生成含活性 Cu-C(sp2) 键的中间体。期望建立一组方便和高效的制备具有最大结构和性质多样性的 1,4,5-三取代 1,2,3-三氮唑衍生物的方法。 尝试使用二价铜的双核配合物或螯合物作为 CuAAC 反应的催化剂。利用其配位稳定性降低铜离子残留，实现在生物分子标记反应中的广泛应用。 使用二价铜与氮氧多齿氧化还原配体生成的螯合物为中间体。利用它们高效形成铜-氮键和铜-氧键的能力以及储存和释放电子的特性，期望建立一组温和制备二芳醚和三芳胺类衍生物的方法。

The copper-catalyzed cycloaddition of alkynes and azides (CuAAC) as well as N- and O-arylations have been received significant attentions recently. In these reactions, the processes and results were efficiently modulated by copper ions appeared in different forms of valence and structure. Therefore, we herein proposed the studies on the formations of carbon-nitrogen and carbon-oxygen bonds as well as their applications mediated by dinuclear, polynuclear or chelate complexes of copper. By using 1-copper alkynes as precursors, a group of procedures will be established for efficient synthesis of 1,4,5-trisubstituted 1,2,3-triazoles, which possess the most structural and property diversity. The key strategy is that 1-copper alkynes have polymeric polynuclear complex structures and the Cu-C(sp) bonds have extremely chemical stability. But, they could selectively carry out the cycloaddition with azides to convert into 5-copper(I) 1,2,3-triazole intermediates with active Cu-C(sp2) bonds. We also try to use dinuclear or chelate complexes of copper(II) as highly efficient catalysts for CuAAC reaction, by which the ionic residue of copper will be reduced extremely in the reaction systems during all processes. Therefore, some procedures may be used widely in the bioorthogonal chemical reactions. The chelate complexes of copper(II) with N,O-polydentate non-innocence ligands will be used as intermediates in copper-catalyzed N- and O-arylations. Since these ligands could accelerate the formations of Cu-N and Cu-O bonds as well as they could store and release electrons during catalysis, therefore, a group of mild and efficient procedures will be established for the synthesis of diaryl ethers and triaryl amines, which are the most difficult synthetic targets in copper-catalyzed N- and O-arylations.