目前针对原发性肝癌复发转移的诊断和治疗仍存在特异性及有效性问题，探索和研究能携带抑癌药物无创、高特异性、稳定的分子靶向探针是解决问题的关健。前期研究发现白介素11(IL-11)类似物九环肽对白介素11受体（IL-11R）高表达的肝癌细胞具有特异结合性，而对正常肝、肺及胃肠等器官无结合。本项目拟创新性自主合成、构建分子靶向探针，通过病理及生物学等技术，从分子、细胞至组织水平，研究分子探针对Morris Hepatom 3924A肝癌细胞株体外结合位点、特异性、亲和力和饱和度；通过近红外及核素等多模态显像，研究其在肝癌模型体内分布、稳定性、靶向特异结合性，探讨其抗癌作用和机理，为肝癌及转移灶靶向治疗提供新的思路。

Currently there is no specific, effective diagnosis and treatment on hepatocellular carcinoma recurrence and metastasis. the key solution these problems is to explore and research a non-invasive, specific, and stable molecular probe which carried anticarcinogen. Our recent study found that interleukin-11 analogues nine cyclic peptide targeted specific binding to interleukin-11 receptor (IL-11R), which was highly expressed in hepatocellular carcinoma( Morris Hepatom 3924A cell ), instead of normal tissues such as liver, lung, stomach, and intestine. In this study, we would first synthesis the nine cyclic peptide as the targeted probes which was labeled nuclide and near infrared dye, investigate the binding site, specific affinity and saturation using pathology and molecular biology from molecular, tissue and animal levels in vivo, explore the stability, distribution, targeting effects and anti-cancer ability using multi-detection imaging methods with molecular imaging in vivo, provide a new theory for effective targeted therapy on hepatocellular carcinoma recurrence and metastasis.