我们前期研究表明，新疆不同民族冠心病的发病风险存在明显的异质性。我们还发现，血清淀粉样蛋白A(SAA) 基因在新疆不同民族冠心病发病异质性中具有重要的作用。Sels 是SAA 的受体，在炎症反应、糖尿病及动脉硬化的发生发展中扮演重要的角色。我们前期研究已经证实Sels 基因多态性在新疆不同民族中的分布具有明显的差异，并和高脂血症具有明显的关联。因此我们推测Sels 基因与新疆不同民族冠心病的发病异质性存在关联。本项目首先采用病例-对照研究分析Sels 基因多态性与新疆不同民族冠心病的关联；并利用Western blot 技术及免疫细胞化学法研究Sels 基因在冠心病患者主动脉组织及内皮细胞中的表达情况；利用基因沉默及过表达技术在细胞水平上验证Sels 基因的功能，阐明其在不同民族冠心发病异质性中的作用及机制。

Previous studies from our center have revealed existence of heterogenity in risk factors for coronary heart diseases (CHD) in different ethnic groups of Xinjiang. Our previous studies have also revealed that serum amyloid protein A (SAA) gene plays important roles in CHD heterogenity in different ethnic groups. Sels is a functional receptor for SAA, and exerts pivotal roles in development of inflammation, diabetes and atherosclerosis, and that genetic polymorphisms of Sels exhibited significant differences in different ethnic groups of Xinjiang and were significantly correlated to hyperdyslipidemia. Therefore, we speculate that Sels gene might be associated with heterogeneity of CHD of different ethnic groups. In this concurrent study using case-control design, we intend to analyze relations of polymorphisms of Sels gene with CHD of different ethnic groups, and using Western blot and immunocytochemical methods, we intend to analyze expression of Sels gene in aortic tissues and epithelial cells to provide theoretical basis for roles and mechanisms for CHD heterogenity in different ethnic groups.