中医药治疗是立足于个体人整体状态的复杂性干预，因此，对整体状态变化的动态测量是辨证论治疗效评价的核心。.申请者在前期工作中建立的个体人健康状态表征参数测量、健康状态辨识方法体系等，能够为中医药临床疗效评价方法研究提供依据。为系统研究整体动态辨识方法在临床疗效评价中的应用及其可靠性，本项目应用系统科学原理及量表、信息等技术，结合国际公认的PRO、CRO等指标，探索建立体现辨证论治的临床疗效评价方法体系。主要内容包括：确立评价参数的采集范围、分级分类及集合筛选原则；形成一体化的临床疗效评价方法体系；通过对评价方案的分析考评，构建疗效评价自动化计算与测量的信息化平台；以450例围绝经期综合征患者为研究对象，对所建立疗效评价方法的可靠性进行验证。旨在以整体状态动态测量为主线，解决当前"以研究目的为导向"的疗效评价体系在整体思维、参数采集、评价指标等存在的不足，为进一步发挥中医临床优势提供科学基础。

TCM treatment is complexity intervention of the overall state of the individual person, so the clinical evaluation must reflect organism thinking of TCM. But the methods of clinical evaluation which currently established for "research purposes" exist shortcomings, its evaluation criteria and results can not fully reflect the characteristics of TCM as a whole, dynamic, personalized diagnosis and treatment..Basing on the former solid work, the claimer supposes the change of whole health state is the core of clinical evaluation, so the methodology system of TCM clinical evaluation will be builded up by scientifically measuring the dynamic whole health state of individuals. The principles and methods of systems will be used in this item and the focus is to find a solution for defects of the original evaluation method such as data acquisition and evaluation methods..The details include: research on the principle of acquisition range, standard,grading and classification, and collection filter of the parameters of clinical evaluation; research on formation of the integrated methodology system of clinical evaluation;to analyze and evaluate the evaluation program, then information platform will be set up and clinical evaluation will be automatically calculated and measured;450 cases of patients with perimenopausal syndrome will be set as confirmatory test subjects to test the reliability of the established clinical evaluation method at the same time..The purpose is to provide a scientific basis for establishing an internationally recognized clinical evaluation method with TCM characteristics, while dynamic measurement of the whole health state being seen as the main line.