胚胎期的环境暴露将决定人体一生的疾病和健康状况，即疾病的发育起源，胚胎期暴露低剂量的环境内分泌干扰物（EDCs）将大大增加机体患糖脂代谢疾病的风险。本项目将从发育编程的角度研究胚胎期暴露EDCs在糖脂代谢疾病发育起源中的作用及机制，研究人群胚胎期暴露EDCs可能导致的糖脂代谢疾病的风险：⑴利用出生队列评估城市和农村孕妇常见EDCs的暴露水平；⑵利用动物实验阐明胚胎期EDCs暴露影响糖脂代谢疾病发生的规律，并明确其剂量-反应关系，从表观遗传学和发育编程的角度探讨胚胎期EDCs暴露影响糖脂代谢疾病发育起源的机制；⑶结合机制研究筛选出一批能预警糖脂代谢疾病风险的早期生物标志物，通过分析孕期EDCs暴露水平对早期生物标志物的影响，以生物标志物为桥梁，作为预警糖脂代谢疾病的风险的指标，并结合儿童期发生肥胖、糖脂代谢异常等的发生情况，最终评价胚胎期暴露EDCs导致生命各阶段发生糖脂代谢疾病的风险。

Environmental exposure during early development play a crucial role in one’s lifetime health and ultimately result in a disease state. There are evidences that embryonic exposure to low-dose environmental endocrine disruptors (EDCs) will significantly increase the risk of adult metabolic diseases. Birth cohort will be involved in to study the influences and associated mechanisms of embryonic EDCs exposure on adult metabolic diseases based on the concept of developmental programming. This project will focus on the following research contents: (1) To estimate the exposure level of common EDCs of both urban and rural pregnant women in our population-based birth cohort. (2) Animal model will be established to clarify the effects of embryonic EDCs exposure on metabolism diseases in adulthood. The dose–response/effect relationship will also be identified. We will explore the epigenetic and developmental reprogramming in the mechanism of embryonic EDCs exposure-induced adult metabolic diseases. (3) Based on the mechanism research, biomarkers which could early predict the risk of adult metabolism diseases will be screened. Finally, we will estimate the EDCs-induced risk of metabolic diseases by changing the biomarkers.