慢性荨麻疹是一种常见的过敏性皮肤病。中医药当归饮子方是目前治疗慢性荨麻疹的常用方剂之一，在防治荨麻疹的发作上有较好的作用，但缺乏治疗慢性荨麻疹的现代科学证据支撑。研究表明，辅助性T细胞失衡是诱发变态反应性疾病的关键因素。自噬是真核细胞的一种防御和保护机制，具有重要意义。我们前期研究发现，当归饮子能通过调节T细胞功能减缓慢性荨麻疹的发生发展，所以我们提出假设，慢性荨麻疹的进展过程中可能存在T细胞的自噬现象，并且中药当归饮子可能通过调控T细胞的自噬，改善Th1 /Th2失衡。我们拟于在大鼠荨麻疹样过敏模型上，观察T细胞表达、功能的变化及自噬的情况；明确当归饮子在诱导T细胞自噬中的作用及可能的作用机制。为慢性荨麻疹的防治和药物的开发提供新的思路和靶点，为中医药防治荨麻疹的机理开辟一个新方向。

Currently, the traditional Chinese medicine Dang Gui Yin Zi is frequently used in clinical treatment of chronic urticaria, and has expressed satisfactory therapeutic effect on it. However, few scientific evidence have been found for the effect. Studies revealed that helper T cells dysfunction was a key factor in inducing allergic diseases, and autophagy was an important defence and protection action of eukaryotic cells. Our preliminary research found that Dang Gui Yin Zi could regulate the T cells' functions so that to slow down the development of chronic urticaria. From that, we proposed a hypothesis that there might be T-cell autophagy in the progression of chronic urticaria. Moreover, Dang Gui Yin Zi might regulate the the autophagy of T cells, which finally improves the Th1/Th2 imbalance. We intended to establish a rat model of urticaria-like allergic, in which, the expression, function variation and autophagy of T cells would be observed. Besides, the effect and potential mechanism of Dang Gui Yin Zi on T cells' autophagy would be explored. The prospective results would provide new directions and targets for the prevention and treatment of chronic urticaria, as well as the mechanism exploration of traditional Chinese medicine.