基于“心藏神，肺藏魄”研究当归饮子合麻黄调控慢荨痒觉环路的效应机制

瘙痒是慢性荨麻疹（CU）常见、顽固性症状，研究安全长效的止痒方法意义重大。慢性荨麻疹瘙痒症状与“心藏神，肺藏魄”密切相关，且临床研究发现，当归饮子可显著缓解CU瘙痒，与麻黄合用则“止痒”效果更佳，但详细机制不明确。最新研究发现，皮肤屏障-免疫-神经三者组成的“痒觉环路”在CU瘙痒中扮演着关键角色。由此，本研究拟通过动物及细胞实验，运用功能磁共振成像BOLD-fmRI、western-blot、qRT-PCR等技术，验证“当归饮子合麻黄通过调控皮肤屏障-免疫-神经痒觉环路从而缓解慢性荨麻疹瘙痒”的科学假说，对CU瘙痒症的“痒觉环路”皮肤屏障-免疫系统-神经系统的关键分子进行检测分析，揭示当归饮子合麻黄治疗CU瘙痒的效应机制。以期丰富中医经典理论“心藏神，肺藏魄”的理论内涵，为当归饮子合麻黄缓解CU瘙痒症的临床推广提供现代科学依据。

Pruritus is a common and stubborn symptom of chronic urticaria (CU). It is of great significance to study a safe and long-term antipruritic method. Chronic urticaria pruritus is closely related to "heart storing spirit, lung storing soul". Clinical research shows that Angelica Decoction can significantly alleviate CU pruritus, and the combination with ephedra has better effect of "antipruritis", but the detailed mechanism is not clear. According to the latest research, the "itch sensation circuit" composed of skin barrier immune nerve plays a key role in the pruritus of CU. Therefore, through animal and cell experiments, using functional magnetic resonance imaging BOLD-fMRI, Western blot, qRT-PCR and other technologies, this study intends to verify the scientific hypothesis that "Angelica Decoction and ephedra can alleviate chronic urticaria pruritus by regulating skin barrier immune nerve pruritus circuit", and promote the key molecules of skin barrier immune system nervous system of pruritus of CU The effect mechanism of Angelica Decoction Combined with Ephedra on pruritus of CU was revealed. In order to enrich the theoretical connotation of the classical theory of traditional Chinese medicine "the heart hides the spirit, the lung stores the soul", and provide modern scientific basis for the clinical promotion of Angelica Decoction and ephedra to alleviate pruritus of CU.