慢性荨麻疹(CU)是一种常见的顽固性皮肤病。课题组前期临床调查数据和文献检索结果显示CU好发于夜间。研究发现IgE介导的肥大细胞脱颗粒和信号传导具有24小时昼夜节律变化，课题组提出假设：CU好发于夜间，与肥大细胞中的Per2时间基因在晚上水平升高相关，“少阴有余”致“营卫”夜间循行失衡诱导了CU夜间的发病，当归饮子可能通过调控生物钟核心基因的表达减缓CU的发生发展。本项目将致力于探明CU发作与昼夜节律的关系，并基于“少阴有余”理论的指导研究当归饮子对CU肥大细胞脱颗粒和昼夜节律核心基因Bmal1、Per2、Cry1及蛋白的调控。预期将为皮肤病与时间节律的研究打开突破口，为临床择时给药原则提供具体的科学指导。

Chronic urticaria (CU) is a common form of intractable skin disease. Pre-clinical research group data and literature search results show CU occur at night. The study found that IgE-mediated mast cell degranulation and signal transduction with 24-hour circadian rhythms, the research group made the hypothesis: CU occurs in the night, and mast cells Per2 time gene in the evening at elevated levels, "Shaoyin more than "To" Ying Wei "imbalance of circulation induced the incidence of CU night, Angelica Yin may regulate the expression of the core gene of the clock to slow the development of CU. This project will focus on the relationship between CU seizures and circadian rhythms. Based on the "Shaoyinyouyu" theory, this project will focus on the regulation of CU mast cell degranulation and circadian rhythm core genes Bmal1, Per2, Cry1 and protein. Will open a breakthrough for the study of skin diseases and time rhythm, provide specific scientific guidance for the principle of clinical timing delivery.