钛金属具有质轻、高强度、耐腐蚀以及优良生物相容性等优异特点，被作为生物医用植入材料广泛应用。钛种植体的细菌感染问题已经成为不同学科领域中的一个重要的研究课题。本课题选择具有生物相容性的PEG/OEG类化合物作为底层构建体，通过有序组装在钛金属表面构筑抗细菌粘附聚合物分子刷，研究其分子结构与表面形貌之间的关系。以该自组装聚合物分子刷为模板，引入广泛存在于生物体内的AMP膜层并借助不同的分子间作用力、配位键等将Ag离子引入模板中，还原后制成Ag NPs/AMP复合杂化体系。研究这种杂化体系的结构、形貌以及不同维度、不同尺寸无机纳米结构的制备条件与方法。研究这种Ag NPs/AMP复合杂化体系作为钛植入体表面膜层的抗菌性能、毒副作用和生物相容性。寻找杂化材料的功能与分子结构以及聚合物分子刷表面形貌之间的关系。探索设计、制备更高性能钛植入体表面杂化生物相容性抗菌膜层材料的新思路和新方法。

Titanium and its alloys are widely used in implantology because of their low weight, high strength, high corrosion resistance and good biocompatibility. Bacterial infection of titanium implants has been an important issue in different fields. In this project, PEG/OEG molecules with excellent biocompatibility are chosen to form polymer brushes on titanium surface to inhibit bacterial adhesion. The AMP molecules, widespread in organisms, are assembled on the polymer brushes layer. Subsequently, the silver ions are introduced into AMP layer by intermolecular forces or coordinate bond, to form Ag NPs/AMP composite hybrid system after reduction. The structure and surface morphology are studied, and the method for preparing nanoparticles (NPs) with different dimensions and sizes are investigated. Furthermore, the antibacterial activity, cytotoxicity and biocompatibility of the Ag NPs/AMP composite hybrid system are investigated. The relationship between the function and molecular structure/surface morphology is elucidated. The new idea and method of preparing antibacterial hybrid coating with good biocompatibility and low toxicology for titanium implants are explored.