外周性眩晕常与焦虑等情绪障碍共病，前庭功能障碍和焦虑情绪之间相互作用并相互影响 。近年研究表明终纹床核是介导焦虑情绪的最重要核团之一，它与多个脑部区域有密切的结构 和功能联系。然而，终纹床核和前庭核之间是否存在神经通路及相互间作用机制仍缺乏相关研 究。本研究应用光遗传学技术，对外周前庭功能损伤动物模型的前庭核和终纹床核分别进行特 异性光刺激，观察前庭核与终纹床核之间的神经通路联系；然后通过焦虑行为学和平衡功能检 测观察实验动物的焦虑水平和平衡能力变化以明确前庭核-终纹床核与眩晕-焦虑反应的相关性 ；最后通过碳纤维微电极技术实时检测前庭损伤动物终纹床核和前庭核单胺类递质的变化规律 及相互联系。本研究将通过光遗传学、电生理学、免疫组化和行为学等手段探索前庭核和终纹 床核之间的结构和功能联系，明确眩晕和焦虑共病的机制，为其综合性诊治提供理论依据。

The comorbidity of peripheral vertigo and anxiety disorder is very common in the clinical practice, vestibular dysfunction has interaction and influence with anxiety. Recent studies show that bed nucleus of the stria terminalis is one of the most important nuclear mediated anxiety, it is related closely with the structure and function of several brain regions. However, the neural pathway and interaction mechanism between bed nucleus of the stria terminalis and vestibular nucleus is still lack of related research. In this study we applies the optogenetics technology, specific light stimulate respectively vestibular nucleus and bed nucleus of the stria terminalis in vestibular dysfunction animal model, observe the neural pathway between vestibular nucleus and bed nucleus of the stria terminalis; Then we observe the change of anxiety and balance through anxiety behavior and balance function tests to make clear the correlation between bed nucleus of the stria terminalis-vestibular nucleus and vertigo - anxiety reaction; Finally, we detect monoamine neurotransmitter of bed nucleus of the stria terminalis and vestibular nucleus in vestibular dysfunction animal model through carbon fiber micro electrode technology. This study we will explore the structure and function relationship of bed nucleus of the stria terminalis and vestibular nucleus through optogenetics, electrophysiological, immunohistochemical and behavior methods, to make clear the mechanism of comorbidity of vertigo and anxiety and provide theoretical basis for its comprehensive diagnosis and treatment.