Preliminary study on the mechanism underlying the interaction of balance dysfunction and anxiety disorder
Preliminary study on the mechanism underlying the interaction of balance dysfunction and anxiety disorder
复制标题
平衡功能障碍与焦虑障碍交互作用机制的初步研究
DOI：
10.1097/wnr.0000000000000977
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发表时间：
2019-01
期刊：
影响因子：
1.7
通讯作者：
Chunsun Fa
中科院分区：
文献类型：
--
作者：
翟丰;石芳;汪靖;戴春富;Chunsun Fa
本研究旨在探究鼓室内注射庆大霉素（GT）诱导的平衡障碍模型中，与焦虑相关的行为变化，以及平衡/焦虑相关神经核内单胺类神经递质浓度的改变。对……进行了鼓室内注射GT（此处“administrated int”表述似乎不完整，推测应为“administrated into”之类，完整句子意思会更明确） 。
This study aims to explore the anxiety-related behavioral changes and the concentration alterations of monoamine neurotransmitters in balance/anxiety-related nuclei of intratympanic gentamicin (GT)-induced balance disorder models. GT was administrated intratympanically in the adult male Sprague-Dawley rats to establish the vestibular impaired animal model. Rotarod was applied to test the vestibular function, and elevated plus maze and open field test were harnessed to evaluate the anxiety level. Monoamines and their metabolites were assayed by high-performance liquid chromatography. Rotarod test revealed that 6 days after GT administration, the average latency decreased significantly compared with the control group. Three days after GT administration, the travel distance and the central zone time obtained from open field and the duration of open arm stay and the times of open arm entries from elevated plus maze were apparently lower than those of the control group, whereas no significant differences were noted between 2-week group and the control group. Three days after GT administration, the concentration of norepinephrine (NE) and 5-hydroxyindoleacetic acid (5-HIAA) within medial vestibular nucleus (MVN); the concentration of NE, serotonin (5-HT), and 5-HIAA within locus coeruleus (LC); and the concentration of NE, 5-HT, 5-HIAA, and 3,4-dihydroxyphenylacetic acid within dorsal raphe nucleus (DRN) increased significantly compared with the control group. Two weeks after the administration, the concentrations of part of the neurotransmitters were lower than those of the 3-day group, indicating the rapid activation and slow deactivation of MVN-LC and MVN-DRN pathways. Vestibular impairment could lead to elevated anxiety level. The elevated anxiety levels might be attributed to increased monoamine concentrations within MVN, LC, and DRN.
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影响因子：
1.4
作者：
Robert S. Kimura;Kwang-Sun Lee;Cynthia L. Nye;J. A. Trehey
通讯作者：
Robert S. Kimura;Kwang-Sun Lee;Cynthia L. Nye;J. A. Trehey
影响因子：
2.8
作者：
Kawamoto K;Izumikawa M;Beyer LA;Atkin GM;Raphael Y
通讯作者：
Raphael Y
DOI：
10.3233/ves-1996-6403
发表时间：
1996
期刊：
Journal of vestibular research : equilibrium & orientation
影响因子：
--
作者：
H. Cransac;L. Peyrin;F. Farhat;J. Cottet-Emard;J. Pequignot;A. Reber
通讯作者：
H. Cransac;L. Peyrin;F. Farhat;J. Cottet-Emard;J. Pequignot;A. Reber
影响因子：
2.5
作者：
Hirvonen, TP;Minor, LB;Carey, JP
通讯作者：
Carey, JP
影响因子：
2.9
作者：
Balaban, CD
通讯作者：
Balaban, CD