西藏地区藏族慢性鼻窦炎炎症免疫表型机制的研究

慢性鼻鼻窦炎严重影响人类健康生活，并带来沉重的社会经济负担。虽然根据现有研究成果能够初步解释慢性鼻窦炎发病的病理生理学机理，然而随着疾病模式的改变和其发病机制的深入研究发现慢性鼻窦炎发病病因及机理因种族、区域环境及遗传性而存在差异。我们的前期研究对此也进行了证实。据此，我们推测由于西藏地区藏族人群因受遗传、恶劣的自然环境、宗教以及历史等因素影响，该人群中慢性鼻窦炎可能有其独特的临床特性和分子免疫学发病机制。由于多种原因，该地区关于CRS方面的研究几乎为空白。因此我们拟通过对西藏地区藏族人群慢性鼻窦炎的临床资料进行分析总结，并结合过敏原皮肤点刺试验及鼻腔分泌物细胞培养，深入免疫系统研究包括；免疫荧光系统检测细胞因子、PCR技术基因检测、免疫组化组织学观察、以及体外刺激试验等方法对该人群CRS的临床特征和发病机制进行较深入的研究，从而丰富CRS的理论基础，为有效治疗CRS提供科学依据。

Chronic rhinosinusitis is a considerable and increasing health problem that places a large financial burden on society. Although the pathophysiology mechanisms of CRS could be initially explained by the available study the changing of disease mode and further study，variation on it may appear among different race， area and heritage. Our prophase study also proved this deduction. So we suppose that CRS of Tibetan is characterized special clinical feature and molecular immunological pathogenesy，because of Tibetan's heritage, bad living environment condition, religion etc. However, there is no any research record about CRS of this area up to now,So we plan to study the clinical feature and pathogenesy of Tibetan's CRS by summarizing clinical datas combining with nasal swabs for microbiological evaluation, immunoassay assessment for several key cytokines and mediators ,qPCR assessment for relative transcription factors, immunohistochemical evaluation for key inflammatory cells,and stimulation test in vitro. Finally with the theory of CRS enriched,it would provide more scientific evidence to cure CRS，especially for Tibetan.