随着种植材料和技术的不断发展，越来越多的患者选择种植义齿修复牙列缺损或缺失。种植体获得骨结合是种植义齿修复成功的标准，而种植体周围炎是骨结合的丧失并最终导致种植义齿修复失败的重要并发症。目前虽有文献报道 T 细胞相关细胞因子在种植体周围炎的病损组织中有表达，但 T 细胞是否参与种植体周围炎的发生发展过程未见详细报道。因此，本课题在前期研究的基础上从种植体周围炎的患者和动物模型体内检测 T 细胞亚群分化相关基因的表达，通过细胞生物学实验研究T 细胞亚群对犬颌骨骨髓间充质干细胞生物学和免疫学特性的影响，明确特异性 T 细胞亚群在种植体周围炎发生发展过程的调控规律。最后通过抗体中和实验，探讨针对特异性 T 细胞亚群的有效抗体模拟液的配制和应用，以减弱炎症并平衡种植体周的免疫状态。本课题从 T 细胞免疫的角度系统深入研究种植体周围炎的发生机制，探讨炎性骨缺损的免疫治疗方法。

As implant material and technology develops, more patients are inclined to dental implants for restoring dentition defects. Osteointegration between implant and alveolar bone is the gold standard for successful implantation. Nevertheless, peri-implantitis is the major reason for loss of osteointegration and failed implant restoration. Despite it has been reported that T cell-related cytokines were expressed in peri-implantitis lesions, whether T cell is involved in this inflammatory process is still unknown. Therefore, based on our previous research we will examine the expression level of T cell subsets from peri-implantitis patients and animal models to determine the specific subsets.Next, to investigate the probable effect and mechanism of T cells subsets under peri-implantitis environment, MSCs and T cells are co-cultured in vitro. Finally, specific neutralizing antibodies are used to ameliorate the inhibition effect of T cell subset to balance the local immune status. Thus, the efficient combination of these antibodies are employed to prepare a simulation to reconstruct the local immune environment. This study explores the mechanisms of peri-implantitis and immune treatment for bone defects from T cell subsets angle for the first time.