外伤后细菌性致死性肉芽肿（FBGT）是本课题组发现并命名的新疾病。该病病情凶险、预后极差,在我们的探索有所突破前，患者100%在1-4年内死亡。目前，我们成功治愈了部分患者，但仍有近半数患者的生命未得以挽救，其原因在于该病的发病机制仍未充分阐明。本课题组现已明确了痤疮丙酸杆菌（P.acnes）为该病病原菌，并发现患者皮损和脑部病变组织内均表现为巨噬细胞浸润为主的炎性改变。电镜观察发现，浸润的巨噬细胞内有大量未被消化、杀灭的细菌，提示巨噬细胞的功能异常可能是该病发生的关键。本课题拟通过分离患者与正常人的巨噬细胞，在经P.acnes刺激后，进一步确认FBGT患者巨噬细胞的吞噬杀菌功能及细胞因子分泌等方面是否存在异常、存在何种异常，并通过基因表达分析和蛋白组学方法，寻找该病发病的具体分子机制。最终通过基因工程手段，构建该疾病的细胞及小动物模型，为阐明FBGT的发病机制及指导临床救治患者提供实验

Fatal bacterial granuloma after trauma (FBGT) was a new disease found and named by our research team. The prognosis of FBGT is dismal, and before we recognized the disease and introduced our treatment plans, all the patients suffered from FBGT died in one to four years. The pathogenesis of FBGT was still unclear, as a result, nearly half of the patients were still unsaved. Now, we have found that Propionibacterium acnes (P.acnes) was the pathogens responsible for FBGT, and marophages were found in the lesion of skin and brain. In addition, scanning electron microscopic image showed that there were many live P.acnes in intracytoplasm of macrophage. As a result, we hypothesized that the aberrant function of macrophage may cause the progression of FBGT. In order to verify the hypothesis, we tend to perform following experiments. Firstly, macrophages will be isolated from patients and healthy persons, then be stimulated by P.acnes. The function of macrophages, including phagocytosis and killing activity, will be examined in vitro to confirm the aberrant function of macrophage in FBGT. Secondly, microarray and proteomics methods will be performed to research the specific molecular mechanism involving FBGT process. Finally, cell and animal models will be established to verify our hypothesis, and they will provide evidence to FBGT treatment.