癌症（恶性肿瘤）是我国以及全球主要的公共健康问题，而癌症化学治疗中广泛使用的具有生物毒性的抗癌药物通过患者排泄进入废水和环境造成污染。但常规污水处理技术和常见的高级氧化手段无法有效控制其在环境中的危害，急需研究可以在医院和污水处理厂等源头高效降解这类化合物的处理技术。本课题计划以上海市主要医院、污水处理厂和河流作为研究对象，对我国使用量大、毒性强的典型难降解抗癌药物开展详细的环境化学行为研究，探讨其污染特性和环境风险。在环境浓度下，进一步利用电子束辐照技术对污水中此类污染物进行高效去除，并研究环境因素的影响。结合理论分析及试验验证，对药物辐照降解过程、降解特性及相关机理开展详细研究。该研究将有助于明确相关类别污染物在环境中化学行为，阐明电子束辐照技术治理相关污染的可行性，可为相关污染物处理提供理论依据，对保护人体健康以及生态环境具有十分重要的现实意义。

Cancer is the main public health problem in China and the world. The widely used anticancer drugs in chemotherapy are emerging contaminants which pollute wastewater and environment by the excretion of patients. However, the conventional sewage treatment technology and the common advanced oxidation methods are ineffectiveness in controlling their harm to the environment. So it is urgent to develop the technology which is available in removing such compounds in hospitals and sewage treatment plants. Therefore, the pollution characteristics and environmental risk of a large amount of toxic refractory anticancer drugs in the main hospitals, sewage treatment plants and rivers of Shanghai will be investigated, further electron beam radiation technology will be carry out in sewage to removal of such pollutants with study on the influence of environmental factors. Combined with theoretical analysis and experimental verification, the process of drug irradiation degradation, degradation characteristics and related mechanism will be studied in detail. This research will clarify the chemical behavior of the relevant categories of contaminants in the environment, illustrate the feasibility of electron beam irradiation technology in controlling of this pollution. It is very significant that this study provides the basis theory for the sewage emission management to protect human health and ecological environment.