多相互作用协同的纳米尺度多腔室分区结构是生物大分子的典型结构特征。探索人工合成高分子多作用协同分区组装新机制，不仅有助于理解生命功能，还可建立一类高分子功能纳米材料制备新方法，是当今化学和材料科学领域的研究前沿。本项目旨在建立嵌段共聚物多作用协同的程序化分区组装新机制。通过RAFT聚合和水溶液自组装，制备两亲性高分子纳米颗粒，以此调控聚合诱导静电自组装。阐明离子单体可见光引发RAFT室温水溶液分散聚合反应的原位复合效应，揭示聚离子生长链跨尺度原位复合机制，深入理解生长链的原位聚离子复合微区与预组装的非离子型疏水微区的动态关联，从而建立纳米材料分区结构和整体形貌的聚合反应动力学调控新机制。本项目的实施，必将突破现有方法分区不完善和低浓度局限性，为生物科技等领域提供一类功能分区相对独立和整体形貌可控的高分子纳米材料高浓度精准合成新方法，充实并拓展我们最近提出的聚合诱导静电自组装。

Synergistic interactions mediated nanoscale multicompartment heterostructures are ubiquitous in nature's biomacromolecules. The synergistic interactions control of aqueous solution assembly of the artificial polymers into the multicompartment nanostructures is highly promising in terms of providing new insights into living functions, and developing a new strategy for the fabrication of advanced polymeric functional nanomaterials. It represents one of the most attractive research fields in the contemporary chemistry and materials science. This project aims to develop a new strategy for the programmable compartmentalization of the as-assembled block copolymers under the synergistic interactions control. Well-controlled RAFT polymerization and subsequent aqueous solution self-assembly will be employed to prepare amphiphilic polymer nanoparticles, which will be utilized to mediate Polymerization-Induced Electrostatic Self-Assembly during visible light initiated RAFT aqueous dispersion polymerization of ionic monomers. Effect of hierarchical polyion complexation of ionic growing chains on polymerization kinetics will be demonstrated, new mechanistic insights into hierarchical complexation of ionic growing chains will be gained, and the correlation between newly-formed polyion complex domains and pre-assembled nonionic hydrophobic domains will be unveiled. As a result, a new strategy for controlled and scalable preparation of polymeric nanomaterials with distinct internal multicompartment heterostructures and finely defined morphologies can be well established. Predictably, this project will lead to significant breakthroughs in terms of overcoming the limitations of imperfect compartmentalization and diluted conditions suffered in traditional hierarchical assembly, developing a novel method for the controlled and scalable synthesis of biomaterials-oriented polymer multicompartment nanomaterials, and consolidating and going beyond the concept of Polymerization-Induced Electrostatic Self-Assembly proposed most recently by our research group.