高分子金属杂化纳米材料在绿色化学、生物技术、新能源等新兴领域具有广泛应用前景，探索复杂有序结构和开发高级功能是其未来发展方向。本项目拟从分子层面仿生，模仿生物蛋白的金属配位动态构建特征。采用可见光调控室温水溶液迭代RAFT聚合，合成类似肽链氨基酸结构单元、共聚序列各异并具有动态反应特性的伯胺衍生水溶性高分子；筛选维生素B6等醛基化合物；采用铁、钴、镍、铜、锌离子为模板，通过室温水溶液亚组分自组装，制备具有选择性配位和动态交换特性的高分子金属杂化纳米材料。探讨组分和介质对超分子构筑的影响；揭示组装诱导的介质扩散和配位催化等动力学效应；探求水溶性高分子纳米限域的选择性配位和动态交换。本项目的实施，将实现水溶性高分子纳米限域的选择性配位和动态交换及其超分子构筑的动态演变，为设计构建功能仿生的高分子金属杂化纳米材料提供新思路，充实并拓展我们最新提出的可见光调控室温水溶液迭代RAFT聚合新方法。

Polymer-metal hybrid nanomaterials have been proven to be promising in emerging fields of green chemistry, biological technology and new energy source. The exploring of highly-ordered complex structures and also sophisticated functions are the main trend to the future development. This project will learn from the nature at molecular level, mimicking the dynamic features of supramolecular architectures in metalloproteins. To this end, a range of well-defined NH2-based reversibly reactive water-soluble copolymers, which consist of the comonomer units similar to the peptide amino acid structures and have different compositions and sequences of the comonomer units, will be synthesized via visible-light-mediated iterative RAFT polymerization in aqueous media at ambient temperature; a variety of aldehyde-functionalized compounds including vitamin B6 will be selected. These materials will utilized as water-soluble subcomponents. The polymer-metal hybrid nanomaterials that have unique properties of selective coordination and dynamic exchange will be exploited via subcompoment self-assembly in aqueous media at ambient temperature, using the abundent first-row transition metal ions as the templates, such as iron, cobalt, nickel, copper and/or zinc ions that are commonly exist in the natural metalloproteins. The correlation of supramolecular architectures with subcomponent structures and the compositions of aqueous media will be studied. The kinetic effects including the assembly-triggered diffusion control and the coordination-induced catalysis will be explored.The unique properties of selective coordination and dynamic exchange in the nanoscale-confined water-soluble polymers will be developed. Accordingly, this project will shed new light on the effect of the local nano-confinement of water-soluble polymer chains on the unique properties of selective coordination and dynamic exchange, and thus the dynamic evolution of supramolecular architectures. In short, this project will guide us a new avenue towards sophisticated biomimetic functional polymer-metal hybrid nanomaterials, and inevitably extend the applications and new insight into the nature of visible- light-mediated ambient aqueous iterative RAFT polymerization that was most recently developed by our group.