治疗骨髓炎是临床医学的难题，目前有效的方法是将药物直接植入感染区，以清除细菌。但难以根据病灶炎症程度用药，局部血供系统和骨组织的受损也增加了修复的困难。据此，本项目研制一种可基于病灶的炎症程度随体内微环境的酸碱变化实现自动调控药物释放的含铜、锶等元素的硼酸盐生物活性玻璃药物载体，以高效清除细菌感染；在治疗过程中该药物载体还能被矿化为层状羟基磷灰石，以提高骨组织自我修复能力；随之释放的离子又具有促血管形成和促骨细胞增殖的生物协同作用。为构建该新颖的多功能药物缓释系统，研究硼玻璃的结构、组成和优化载体构造，探索与pH响应高分子膜的复合及对宿主微环境和生物性能的影响，综合分析玻璃网络体在生物体内的转归途径及机理，阐明硼酸盐生物活性玻璃的结构及组成在生物矿化、成骨、成血管效应等方面的关键科学问题具有明显的创新性和重要的理论价值，也能够为硼酸盐生物活性玻璃药物载体在骨髓炎治疗中的应用提供实践指导。

The treatment of osteomyelitis is a hard problem in clinical medical, the effective method is to directly inject drugs into the affected areas to remove bacteria. However, it is very difficult to decide the medication according to the degree of inflammation, and meanwhile the damaged local blood supply system also makes it difficult to repair bone tissue. In this research, we developed copper, strontium and other elements contained borate bioglass drug carriers, which can intelligent control the drug release ability according to the change of inflammatory degree based on the pH value of the in vivo microenvironment, so as to effectively clear the infection. During the treatment process, the drug carrier can mineralize into bone lamellar hydroxyapatite to improve the self-repair ability of the tissue. The released ions can promote the biological synergistic effect on angiogenesis and proliferation of osteoblasts. In order to construct a novel multifunctional drug delivery system, it is necessary to study the structure and the composition of borate glass and optimized carrier structure, investigate the influence of recombination with pH responsive polymer membrane and host microenvironment and biological properties, and compressively analysis the path and mechanism of glass network inside the organism. To elucidate the key scientific problems of the biological mineralization, osteoblasts and vascular effects of borate bioglass structure and composition is of obvious innovation and important theoretical value, and will also provide practical guidance for the application of borate bioglass drug carriers in the treatment of osteomyelitis.