肿瘤治疗的主要障碍是肿瘤细胞耐药，肿瘤干细胞被认为是肿瘤耐药、复发和转移的罪魁祸首,从逆转肿瘤干细胞多药耐药的角度探寻肿瘤治疗的策略可能为肿瘤的根除带来希望。我们在前期工作中发现三氧化二砷对乳腺癌肿瘤干细胞和大肠癌肿瘤干细胞杀伤作用明显高于阿霉素、紫杉醇和顺铂。同时三氧化二砷能明显降低乳腺癌干细胞的荷瘤鼠模型中的肿瘤干细胞含量，并且带来很小的副作用。应用三氧化二砷干预乳腺癌干细胞后发现BRCP，ABC蛋白含量明显下降。这极大地鼓舞我们去探索三氧化二砷对肿瘤干细胞的多药耐药的逆转作用和机制，为从根源上治疗肿瘤提供全新的思路。同时纳米材料作为载体的生物医用材料可以制备兼有靶向、缓控释性能的癌症药物新制剂，二氧化锆被公认为是一种良好的复合多功能纳米颗粒的介质。本项目首次提出拟构建二氧化锆装载三氧化二砷的纳米药物制剂，对其杀伤肿瘤干细胞的靶向性和有效性进行鉴定，为探索抗肿瘤耐药提供新药物。

The main obstacle for cancer treatment is resistance of tumor cells, cancer stem cells are thought to be main reason for tumor resistance, recurrence and metastasis, from the view of reversal of multidrug resistance,we explore the cancer treatment may bring hope for the eradication of the tumor. We found in previous work the killing effect of arsenic trioxide on breast and colorectal cancer stem cells was significantly higher than doxorubicin, paclitaxel and cisplatin. Arsenic trioxide can significantly reduce the cancer stem cell content in the tumor-bearing mouse model of breast cancer stem cells, with few side effects.The BRCP, ABC is greatly decreased after the arsenic trioxide intervention in breast cancer stem cells. This greatly encouraged us the reversal of arsenic trioxide on multidrug resistance of cancer stem cells to explore the role and mechanism for the treatment of cancer. Nanomaterials as carrier biomedical materials can be prepared both targeted and controlled release performance of the new formulation of the cancer drug, hollow ZrO2 is recognized as a good composite multifunctional nanoparticles medium. We first propose to build a sandwich silica loading arsenic trioxide nano pharmaceutical preparations, new drug targeting and the effectiveness of its anti-cancer stem cells were identified, to explore the anti-tumor drug resistance drug.