浆液性卵巢癌（serous ovarian carcinoma，SOC）是卵巢恶性肿瘤中最常见而预后最差的亚型。癌症基因组图谱计划（TCGA）对SOC全基因组分析发现FOXM1信号通路在高级别SOC中异常表达的比率高达87%，仅次于P53，但FOXM1在SOC中的分子调控机制尚未阐明。本课题拟通过干预表达，利用体外和体内实验明确其在SOC中的生物学功能；利用ChIP-Seq、luciferase及生物信息学等方法筛选和鉴定FOXM1下游关键分子；并进一步通过组织芯片分析FOXM1及下游分子的表达状况，以明确其与肿瘤发生发展和分子分型及临床预后的相关性。本研究将有助于揭示FOXM1及下游分子网络调控SOC的分子机制，为本病的分子分型和个体化治疗提供新的分子靶标。

Serous ovarian carcinoma（SOC ）is the most common subtype of ovarian malignancies with the worst prognosis. The Cancer Genome Atlas (TCGA) project showed that FOXM1 transcription factor network altered in 87% of high grade serous ovarian carcinoma cases，just lower than P53 expression. However, the biological function and molecular mechanism of FOXM1 and its downstream network need further study. We will first determine the functional effect of FOXM1 on tumorigenesis and metastasis of SOC in vitro and in vivo. Then, ChIP-Seq, luciferase assay and bioinformatics analysis will be used to identify the downstream targets that are physically associated with FOXM1. And finally, we will examine the expressions of FOXM1 and its downstream network in SOC patient samples to determine whether their expressions are correlated with tumorigenesis , molecular typing and clinical prognosis. The ultimate goal of this study is to clarify and characterize the functional role and molecular mechanism of FOXM1 and its downstream network in tumorigenesis and metastasis of SOC and provide new molecular targets for molecular typing and individualized treatment.