基于DNA自组装纳米芯片的分子计算模型研究

DNA计算凭借DNA分子天然的微观分子特异性效应，具有大容量高密度信息存储和并行计算能力，是发展非传统高性能计算的重要途径之一。如何实现DNA计算模型一直是一个有待解决的重要科学问题。近年来，DNA自组装芯片的发展为纳米微观操控提供了坚实的基础，特别是“自底向上”的DNA自组装技术结合纳米颗粒操控技术将为DNA计算提供更多的实现途径和更高的操控精度。因此，本项目拟开展基于DNA自组装纳米芯片的分子计算模型研究。研究内容包括利用纳米颗粒的操控进行数值计算；利用DNA折纸平面上对纳米颗粒进行高密度有序排布，实现大容量信息的存储；基于DNA自组装技术设计逻辑计算元件等；用分子计算模型作为控制模块，设计实现特定功能的智能纳米装置。研究成果将为基于生物材料的信息存储和信息加密提供新方法，以及对海量分子实施并行操控和实时检测的新技术。

DNA molecules have natural micro specific effects, which makes DNA computing has the capabilities such as the large capacity and high-density of information storage, and parallel computing. DNA computing becomes one of important ways to develop non-traditional high-performance computing. However, it remains an important scientific problem how DNA computing models are implemented. In recent years, the development of DNA self-assembly chip provides a solid foundation for the nano manipulation, especially the “bottom-up” DNA self-assembly technology with the nanoparticle manipulation technology provides more ways and better accuracy to implement DNA computing. In this project, we investigate DNA computing models based on DNA self-assembly nano chips. The problems to be investigated include how to do numerical calculation by using the manipulation of nanoparticles; how to store information with high-density and large capacity by orderly arrange nanoparticles on DNA origami plane; how do design and construct logic computing units by DNA self-assembly technology; how to design smart nano devices with specific functioning that use DNA computing models as controls modules. The expected research results include new methods for information storage and encryption based on biological materials, and new technologies for parallel manipulation and real-time detection of massive molecular.