现场制备有机锌：电化学促进的水相Negishi-like交叉偶联反应

过渡金属催化的有机锌与芳卤之间的偶联反应是有机合成的重要反应（Negishi偶联反应）， 该方法可以合成重要的烷基化芳烃。通常该反应需要预先制备有机锌试剂。本项目以电化学为技术，水为溶剂，研究现场制备有机锌的Negishi-like偶联反应。重点研究以锌为电极，通过电解-电镀方式获得的活性锌参与Negishi-like反应的方法。期望发展电化学运用于Negishi偶联反应的新技术。通过研究电化学条件下Negishi-like偶联反应的机理，探索电化学有机合成的新现象、新规律，进一步发展高效、高选择性以及对环境友好的有机合成新方法。

Transition metal-catalyzed cross-couplings of organozinc reagents with aryl halides and pseudohalides (Ar-X) are considered fundamental transition metal mediated C-C bond forming reactions (Negishi Coupling). Such couplings continue to offer a highly valued entry to alkylated aromatic rings. Without exception, preformation of an organozinc halide (RZnI) is required. In this proposal, electrochemical supported Negishi-like Coupling Reaction in water was studied through in situ preparing of organozinc halide. This work will focus on the study of the reaction mediated by "active Zn", which is obtained by the deposition of Zn cations from the dissolution of Zn anode. It represents the first study of applying the electrochemical technique into the zinc mediated, transition metal -catalyzed cross-couplings in water. This new methodology provides a remarkably straightforward means of effecting transition metal catalyzed Csp2-Csp3 bond constructions in the absence of a stoichiometrically preformed organometallic coupling partner. And it is high efficient, selective and environmental friendly.