系统性白色念珠菌感染已经成为一类严重地威胁住院患者生命的感染性疾病。缺乏有效的治疗手段是造成高死亡率的重要原因之一。所以，开展针对白色念珠感染的防治研究具有重要的意义。本项目拟采用噬菌体展示技术和纳米合成技术，开展白色念珠菌治疗的免疫学研究。主要包括三方面工作：（1）双展示HSP90和SAP2抗原表位噬菌体的免疫学基础研究；（2）利用双展示HSP90和SAP2抗体表位噬菌体进行免疫治疗研究；（3）利用噬菌体磁性复合纳米线进行治疗研究。本课题为研制白色念珠菌疫苗奠定理论和方法基础。研究特点：（1）前期研究工作的延伸和深入；（2） 研究手段注重了学科交叉和技术创新。

Systemic candida albicans infection is a life treating disease in hospitalized patients. There is no effective detection and treatment methods in immunocompromised patients, resulting in significant morbidity and mortality. So it is a necessary to develop preventive vaccines and therapeutic vaccines. This project intends to use phage display technology and nanotechnology to develop immunology research of candida albicans diagnosis and treatment. There are there works: (1) phages simultaneously displayed VKYTS peptide and LKVIRK peptide will used to study immunological characteristics . (2) phages simultaneously displayed the specific binding peptides to HSP90 and SAP2 will used to research immunotherapy to candidiasis of the animal . (3) targeting phage composite nanometer materials will used to study immunetherapy and physical therapy. This project aims to lay the foundation for development of vaccine.The characteristics of this project are : (1) the further research based on the our previous works; (2) the research focuses on multi-disciplinary and technological innovation.