阿尔茨海默病(AD)是一种常见的神经系统退行性疾病，其典型病理改变为脑内大量淀粉样蛋白(Aβ)沉积形成的老年斑、tau蛋白过度磷酸化形成神经纤维缠结及神经元丢失。AD的病理特征错综复杂以及血脑屏障(BBB)的难穿透性使得其药物研发举步维艰。因此，寻求高效穿透BBB，减少Aβ产生、自聚集和增强Aβ清除，缓解Aβ触发的tau蛋白过度磷酸化、氧化应激以及神经炎症等的多靶点防治策略，对延缓或阻止AD进展至关重要。我们既往发现装载内源性神经保护肽(GPE)的纳米粒(GQDG)和装载姜黄素的纳米粒(PLGA-PEG-B6/Curcumin)均能高效通过BBB，并证实了GPE与姜黄素具有治疗AD的作用。本研究在此基础上合成了一种MRI可示踪性的GPE与姜黄素共传递的诊疗一体的新型纳米复合物DPBG/GC，拟利用多种细胞、动物模型，从多靶点探究AD的防治方向，为未来纳米材料治疗AD提供新思路。

Alzheimer's disease (AD) is a common neurodegenerative disease with the typical pathologies of Aβ deposition into senile plaques, hyperphosphorylation of tau into neurofibrillary tangles and neuron loss . The intricate pathological features of AD and the poor penetrability of the blood brain barrier (BBB) make it difficult for drug development. Therefore, the search of multi-target prevention and treatment strategies for the effectiveness of the drug penetrating across the BBB, reducing Aβ production and self-aggregation, enhancing Aβ clearance, alleviating Aβ-triggered tau phosphorylation, oxidative stress and neuroinflammation is crucial to AD. We previously found that both endogenous neuroprotective peptide Gly-Pro-Glu (GPE)-loaded nanoparticles (GQDG) and curcumin-loaded nanoparticles (PLGA-PEG-B6/Curcumin) could efficiently pass through the BBB, and proved the promising therapeutic effects of GPE and curcumin on AD. Based on these work, novel theranostic nanomaterials (DPBG/GC) with BBB penetrability and MRI traceability along with GPE and curcumin co-delivering were synthesized. Using a variety of cell and animal models to examine the preventive and therapeutic effects of these nanomaterials on AD from multiple targets, this study will provide new insights for the future treatment of AD with nanomaterials.