The Correlation Between White Matter Hyperintensity Burden and Regional Brain Volumetry in Patients With Alzheimer's Disease.
The Correlation Between White Matter Hyperintensity Burden and Regional Brain Volumetry in Patients With Alzheimer's Disease.
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阿尔茨海默病患者白质高信号负担与区域脑容量之间的相关性
DOI：
10.3389/fnhum.2022.760360
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发表时间：
2022
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
阿尔茨海默病（AD）患者脑内白色高信号（WMH）与局部脑叶萎缩并存，但AD患者二者之间的关联性尚缺乏全面调查和扎实的影像学数据支持。我们探讨了WMH是否可以通过加重特定脑区的萎缩来促进AD的病理过程，并试图解释这些关系的区域特异性。从ADNI数据库中抽取了240名成年人，包括180名正常对照（NC）和80名AD患者。下载参与者的T1加权磁共振成像（MRI）和T2加权液体衰减MRI，并使用AccuBrain®进行分析，以生成WMH（WMHr，WMH体积经颅内体积校正）和局部脑萎缩的定量比率。我们还将WMHr分为室周WMHr（PVWMHr）和深部WMHr（DWMHr）。胆碱能途径高信号量表（CHIPS）评分由两名评价者进行。采用独立t检验、Mann-Whitney U检验或χ2检验比较人口统计学特征，并采用斯皮尔曼相关系数值确定WMH与不同脑萎缩区域之间的关联。在Bonferroni校正前，AD组中发现WMHr与定量内侧颞叶萎缩（QMTA）（rs = 0.281，p = 0.011）、颞叶萎缩（rs = 0.285，p = 0.011）和岛叶萎缩（rs = 0.406，p < 0.001）之间呈正相关。PVWMHr有助于这些相关性。分别分析PVWMHr与脑萎缩的关系，发现AD组校正后QMTA（rs = 0.325，p = 0.003）、颞叶萎缩（rs = 0.298，p = 0.007）、岛叶萎缩（rs = 0.429，p < 0.001）仍呈正相关。WMH的严重程度往往与AD患者的局部脑萎缩相关，尤其是内侧颞叶、颞叶和岛叶萎缩。PVWMH致力于这些相关性。
White matter hyperintensities (WMHs) and regional brain lobe atrophy coexist in the brain of patients with Alzheimer's disease (AD), but the association between them in patients with AD still lacks comprehensive investigation and solid imaging data support. We explored whether WMHs can promote the pathological process of AD by aggravating atrophy in specific brain regions and tried to explain the regional specificity of these relationships. A sample of 240 adults including 180 normal controls (NCs) and 80 cases with AD were drawn from the ADNI database. T1-weighted magnetic resonance imaging (MRI) and T2-weighted fluid-attenuated MRI of the participants were downloaded and were analyzed using AccuBrain® to generate the quantitative ratio of WMHs (WMHr, WMH volumes corrected by intracranial volume) and regional brain atrophy. We also divided WMHr into periventricular WMHr (PVWMHr) and deep WMHr (DWMHr) for the purpose of this study. The Cholinergic Pathways Hyperintensities Scale (CHIPS) scores were conducted by two evaluators. Independent t-test, Mann–Whitney U test, or χ2 test were used to compare the demographic characteristics, and Spearman correlation coefficient values were used to determine the association between WMHs and different regions of brain atrophy. Positive association between WMHr and quantitative medial temporal lobe atrophy (QMTA) (rs = 0.281, p = 0.011), temporal lobe atrophy (rs = 0.285, p = 0.011), and insular atrophy (rs = 0.406, p < 0.001) was found in the AD group before Bonferroni correction. PVWMHr contributed to these correlations. By separately analyzing the relationship between PVWMHr and brain atrophy, we found that there were still positive correlations after correction in QMTA (rs = 0.325, p = 0.003), temporal lobe atrophy (rs = 0.298, p = 0.007), and insular atrophy (rs = 0.429, p < 0.001) in AD group. WMH severity tends to be associated with regional brain atrophy in patients with AD, especially with medial temporal lobe, temporal lobe, and insular lobe atrophy. PVWMHs were devoted to these correlations.
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DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
29
作者：
Haight, Thaddeus J.;Landau, Susan M.;Carmichael, Owen;Schwarz, Christopher;DeCarli, Charles;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
29
作者：
Kester, Maartje I.;Goos, Jeroen D. C.;van der Flier, Wiesje M.
通讯作者：
van der Flier, Wiesje M.
影响因子：
4.8
作者：
Franchetti MK;Bharadwaj PK;Nguyen LA;Van Etten EJ;Klimentidis YC;Hishaw GA;Trouard TP;Raichlen DA;Alexander GE
通讯作者：
Alexander GE
影响因子：
9.9
作者：
FAZEKAS, F;KLEINERT, R;LECHNER, H
通讯作者：
LECHNER, H