基于程序性死亡配体-1对调节性T细胞的调控探讨肺肠合治法治疗干燥综合征的作用机制

肺肠合治法是治疗干燥综合征（SS）的有效方式，其能宣肺布津，增液润肠，临床疗效确切。本课题组前期研究发现，麦冬地芍汤可能通过血管活性肠肽(VIP)提高调节性T细胞（Treg）的比例，起到改善SS症状的作用，但其中的具体作用机制不明。研究Treg细胞在干燥综合征的作用和调节机制为肺肠合治法带来了新的科学理论依据和前景。相关文献及研究表明，VIP对Treg细胞的促进作用可能与PD-L1的生理效应关系密切， PD-L1对Treg细胞的作用可能通过PD-1/PD-L1通路，也可能与CD80的相互作用相关。本课题组拟从PD-L1切入，探究麦冬地芍汤通过VIP调节Treg细胞的作用机制，对干燥综合征治疗的机制进行更进一步的探讨。

Combination of Diffusing Lung and Lubricating Intestine is an effective clinical approach for Sjogren’s syndrome(SS), considering its apparent therapeutic effects by means of diffusing Lung, redistributing body fluid and lubricating Intestine. Previous studies showed that when SS is treated this way, better immune tolerance and alleviated clinical symptoms were observed in relation to the upregulation of Regulatory T cells(Tregs). It is probably mediated by vasoactive intestinal peptide(VIP), where the detailed mechanism remains unclear. Studies on the effects and regulation of Tregs have brought brand new explanations and potential prospective for the Combined Diffusing Lung and Lubricating Intestine in treating SS. Researches have showed a strong correlation between PD-L1 and positive regulation in Tregs from VIP. But since PD-L1 can interact with both PD-1 and CD80, and perform different functions respectively, further studies are needed to confirm the actual mechanism behind it, shedding new light on the treatment for Sjogren’s syndrome.