小脑不仅是皮层下重要的运动调控中枢，而且在机体躯体-非躯体反应整合中发挥关键作用（Zhu et al: Brain Res Rev, 2006），其损伤导致的运动共济失调，往往伴发内脏或情感障碍（如焦虑等），即躯体-非躯体并发性功能失调。促肾上腺皮质激素释放因子（CRF）作为脑内一种广泛分布的肽类神经递质，参与了机体许多生理功能和病理过程的调节。然而有趣的是，神经解剖学研究提示小脑中存在大量的CRF能神经纤维传入，但对其功能迄今不明。因此，本项目拟在我们先前工作基础上，从整合神经生物学角度，在分子、细胞、神经元环路和系统行为水平上，深入研究小脑CRF能神经传入在经小脑神经环路的运动调控和情感调节中的作用和机制，及其与小脑共济失调和焦虑症的关系。研究结果将不仅有助于在基础理论上深入认识行为反应中躯体运动与非躯体情感活动的整合机制，也将为临床治疗小脑运动疾病和情感障碍，以及两者共病提供新思路。

The cerebellum, an important subcortical center for motor control, holds a key position in somatic-nonsomatic integration (Zhu JN et al: Brain Res Rev, 2006). In clinic, cerebellar lesion often induces a simultaneous somatic and nonsomatic dysfunction, i.e., cerebellar ataxias accompanied by visceral or emotional disorders, including anxiety. As a peptide neurotransmitter extensively distributed in the brain, corticotropin-releasing factor (CRF) participates in the regulation of various physiological functions and pathological processes. Intriguingly, there are abundant CRFergic afferents in the cerebellum, however, their roles remain enigmatic. Thus, on the basis of our previous studies on somatic motor and nosomatic functions of the cerebellum, we will investigate, from the perspective of integrative neurobiology, on the function of cerebellar CRFergic afferent inputs in the motor control and emotional regulation via the cerebellar neuronal circuitry and its underlying mechanisms, at molecular, neuronal, circuit, and behavioral levels. Furthermore, the relationship between the cerebellar CRFergic afferent inputs and ataxia as well as anxiety will be determined. The results will not only contribute to our understanding of mechanisms underlying the integration of somatic motor and nonsomatic emotional components in behavioral responses in basic theory, but also help to provide a new insight into clinic treatment of cerebellar motor diseases, emotional disorders and the comorbidity of motor diseases with emotional disorders.