功能性腹痛综合症（FAPS）因对患者造成长期慢性疼痛和对医疗资源的过度占用，且发病机制不明、无有效治疗措施，已得到国际镇痛医学界的高度关注。"脑-肠"双向交互模型以及前期临床研究结果，推测FAPS疼痛是由正常内脏输入信号在脑内异常调节所导致，即内感受的中枢传入或调控网络存在异常，但具体脑内机制尚不清楚，神经影像学的发展为研究这一课题提供了有效途径。基于此，本项目拟采用病例-正常对照实验设计，运用脑结构、DTI和静息态fMRI，从结构和功能两方面揭示FAPS脑稳态传入/调控网络、固有网络、复杂网络的异常节点、效应连接和拓扑属性，同时采用任务态fMRI，探寻认知和情感因素对脑特殊结构域功能和静息状态下脑网络节点的影响；并将网络研究结果与临床病程、痛觉评估作相关分析。以期从结构和功能上探明FAPS脑痛觉异常网络调控模式，为理解FAPS的发病脑机制及治疗靶点的选择提供新的依据。

Functional abdominal pain syndrome (FAPS) can lead to long-term chronic pain to patients and over occupation of the medical resources. Due to the unknown pathogenesis, there is currently no effective treatment to patients with PAFS, which has caused a great concern of the international analgesic medicine. The brain-gut interaction and the results of pre-clinical studies suggested that abdominal pain was caused by abnormal central regulation of normal visceral input (i.e., the homeostatic afferent network or top-down regulation network is abnormal). However,the specific neural mechanisms is not clear. The development of neuroimaging provides an effective way for the study of this subject. In line with the current situation, we intend to adopt a case - control design, and use multi-modal neuroimaging to investigate abnormal nodes, abnormal effect connect and abnormal topological properties of brain network on two aspects of the structure and function. We also used task-state fMRI to detect the effect of cognitive and emotional factors on brain special domain and the nodes of resting-state brain network. At last, we perform correlation analysis to reveal the relationship between the results from network and clinical course and pain scale. It is hope that our findings could reveal the patterns of brain connectivity in the regions of pain regulation in FAPS, which in turn extend our understanding of the pathophysiology of FAPS, and provide new evidence for treatment for FAPS.