原发性痛经是青年女性最常见的妇科紊乱疾病之一，发病率高，严重影响青年女性的日常生活。其病理生理机制仍不十分明确，缺乏客观有效的诊断辅助检查。本课题根据女性月经周期多个时间点（排卵期、经前3天、月经当天），联合多模态磁共振成像技术、盆腔磁共振成像技术以及临床血液检验方法对原发性痛经女性的大脑结构和功能、盆腔结构数据集以及静脉血液中敏感的痛经相关内分泌指标进行综合对比分析，同时考察特定时间点下痛经相关的移情任务下大脑功能异常变化，试图寻找原发性痛经大脑结构-功能异常与敏感内分泌指标以及子宫结构变化之间的交互作用关系，通过观察大脑移情功能异常研究痛经如何通过中枢对行为学产生影响，建立“中枢-内分泌-子宫”关联模型，探索原发性痛经的敏感影像学标记，多角度综合分析原发性痛经的发病机制，试图为临床诊断和疗效评价提供可靠的科学理论依据。

Primary dysmenorrhea is one of the most common gynecological disorder in young women, which makes severe impact on women’s daily life. However, the pathogenesis of primary dysmenorrhea is still unclear. The lack of objective and effective auxiliary examination to diagnose this disease restrict the development of primary dysmenorrhea. In this study, according to multiple time points of woman’s menstrual cycle, we detecting the brain structural and functional neuroimaging characteristic and the structural changes of uterus in order to fine the imaging markers of diagnosis and treatment. We also draw blood from primary dysmenorrhic women to examine their abnormal sensitive endocrine changes. By combining the changes of central nervous system, uterus morphology and sensitive endocrine, we try to create an association model to fine their relationships. Besides, every participant were told to finish some behavioral questionnaires test their because of the influence of cyclic menstrual pain. In general, the sensitive biomarker of brain, uterus and endocrine and the creation of the “Brain-Uterus-Endocrine” association model are contributed to explain the pathological mechanism of primary dysmenorrhea in multi-view and to supply scientific theory basis for clinical.