炔醇选择性加氢是维生素产业链中的关键反应之一。工业上普遍采用的Lindlar催化剂不但含有Pb、Bi等有毒、有害的物质，在应用过程中还要加入含N、P、S的有机助剂来进一步提高烯醇的选择性，反应后分离能耗高。本项目从合作企业实际生产中所碰到的问题中提炼科学问题，通过基础研究解决问题后再服务于企业，以基础研究带动产业化应用。项目主要包含两个方面内容：（1）调控氮掺杂炭材料（CN）中不同种类N与Pd之间的相互作用，从研究CN负载的Pd基催化剂（Pd/CN）中Pd电子结构与炔醇加氢活性之间的构-效关系出发，从活性和选择性两个方面优选出最佳的Pd/CN催化剂；（2）在上述工作的基础上，将含N、P、S的“柔性”长链多齿有机助剂固载于CN载体表面，既可以提升目标产物烯醇的选择性，又可以防止有助剂流失于反应液中，简化后续的分离过程。该项目的开展能为炔醇加氢机理研究以及高效催化剂的开发提供新的思路。

Alkynol semi-hydrogenation is of great significance in the synthesis of Vitamins. Conventionally, semi-hydrogenation of alkynols was often carried out on Lindlar catalysts. Lindlar catalysts usually contains CaCO3 as support, palladium as active center and Pb(OAc)2 as modifier. Bi is an alternative metal to Pb. Pb and Bi are both harmful to the environment. Then some organic compounds, possessing nitrogen, phosphorous or sulfur heteroatoms, with a strong interaction to the surface is added to the reaction solution to improve alkenol selectivity. It will cost much to extract these compounds. This proposal mainly includes the following two aspects: (1) N-doped carbon (CN) material supported Pd catalysts (Pd/CN) would be prepared. The electronic property of Pd would be tuned by using several CN materials with different N-containing species distribution; (2) Some flexible polydentate ligands, which can improve alkenol selectivity, would be immobilized on the selected CN material, respectively. Some Pd-based catalysts would be obtained by using these functionalized CN materials as supports. The flexible polydentate ligands can also play a similar role as they are free and they would not leach into the solution. This proposal can pave the way to the exploration of structure-activity relationship in the semi-hydrogenation of alkynols and the design of new catalysts for this reaction.