基于纳米通道的分析和分离是分析化学基础和应用研究的热点领域之一，而纳米通道薄膜的制备仍有很大的挑战。本项目拟在我们前期的工作基础之上，利用表面活性剂分子自组装和有机硅烷分子水解/缩聚反应的协同作用，生长孔道高度有序排列且垂直于电极表面的二氧化硅(SiO2)纳米通道薄膜。首先，以得到的SiO2纳米通道/表面活性剂胶束的二元自组装薄膜为对象，研究有机胶束对疏水有机小分子（与生命健康、公共安全和环境污染等相关）的选择性萃取、预富集和痕量电化学分析方法。重点研究从电极表面剥离制备双通的SiO2纳米通道薄膜及其表界面化学修饰，调控纳米通道孔径、表面电荷和亲疏水性质，实现分子水平的识别和高效分离，剖析纳米通道的表界面效应和离子跨膜过程的界面结构、热力学和动力学问题，并探索与微流控芯片的集成。

Analysis and separation based on nanochannels is one of hot topics in the fundamental and applied analytical chemistry field, in which the preparation of nanochannel film remains to be a big challenging. On the basis of our previous work, this project aims at preparing the highly ordered and vertically aligned silica nanochannels on the solid electrode surface by the co-operative assembly of surfactant templates and hydrolysis/polycondensation of organosilanes. First, we plan to study the selective extraction, preconcentration and electrochemical detection of trace lipophilic yet redox-active organic compounds by the binary assembly of surfactant micelles and silica nanochannels. Then we shall focus on the preparation of free-standing silica nanochannel film and the modification of nanochannels with desired size, surface charge and lipophilicity. The primary goal is to investigate the molecule recognition and separation at the molecular level, as well as the surface/interface effect, the nanoconfinement effect, the thermodynamic and kinetics of molecule transport process. We also plan to combine the free-standing silica nanochannel film with the microfluidic device.