癌性厌食的防治是晚期肿瘤患者的需求，在改善晚期肿瘤患者生存质量方面占有非常重要的位置。本课题将采用wistar大鼠制备大肠癌模型，观察大鼠耳针干预前后的体重及摄食量变化。同时采用ELISA 试剂盒测定大鼠血清瘦素，采用放射免疫法检测食欲素A的含量，探讨耳针对大鼠血清瘦素、食欲素A的影响关系，阐明耳针改善肿瘤患者食欲的可能作用靶点与血清瘦素及食欲素A之间的关联性。通过随机单盲对照临床研究，观察耳针组及对照组肿瘤患者简化食欲量表、进食量、食欲分级、体重、Karnofsky等指标治疗前后的变化，验证耳针改善肿瘤患者食欲的客观临床疗效。在明确中医耳针治疗癌症厌食的临床价值及初步探讨其改善肿瘤患者食欲的可能作用机制，并为癌性厌食的防治提供国际接受度高、安全性高且疗效确切的绿色治疗手段方面有着重要的科学意义。

Controlling of cancer induced anorexia is highly demanded by advanced cancer patients. It plays an important role in improving the quality of life among advanced cancer patients. Our study will use a colorectal cancer rat model to observe the changes of weight and food intake before and after auricular needling treatment.We also test serum leptin of the model by ELISA method and orexinA by radioimmunoassayto discuss the influence and relationship amongauricular needling intervening and serum leptin, orexin. And then we will try to explain the possible effective target of auricular needling treating cancer induced anorexia. Through a randomized controlled single blinded clinical research, we will observe the differences of appetite, food intake amount, weight and KPS between the auricular needling treating group and control group before and after the treatment. Based the results of the research, we can prove the clinical effectiveness of auricular needling in treating cancer induced anorexia and possible mechanism of the method. Thus it will provide a highly international receptive, safe and effective treatment of cancer induced anorexia and has agreat scientific significance.