动物性食品中抗生素残留是食品卫生领域研究的重点之一，分析检测明确食品中抗生素的种类和浓度，是食品污染研究的首要依据。而动物性食品中抗生素浓度低、基质复杂、种类繁多、性质差异大，分析检测困难。而开发研究同时、高效、高通量吸附多种抗生素的样品预处理技术是亟待解决的关键问题。本项目在前期研究工作的基础上，结合固相萃取材料的分子结构和纳米孔径这一新的角度，协同salen-COFs多样化的构筑单元、孔隙率结构的强吸附亲和力的优势，构建功能化修饰salen-COFs材料优选、提取条件优化的样品预处理体系，可同时实现多种抗生素的高效提取。基于高通量预处理方法体系和同时提取不同性质抗生素预处理技术，结合液相色谱建立分析方法，实现动物性食品中抗生素残留的检测，为食品样品中抗生素的分析检测提供高效、精密、准确的方法学基础，并通过应用对我国东部区域动物性食品中抗生素种类和含量的分析检测，进一步验证方法的可行性

Antibiotic contamination in food is one of the focuses in the field of food hygiene. Analysis and detection to determine the type and concentration of antibiotics in food is the primary basis for food pollution research. However,it is difficult to analyze and detect antibiotics in animal food due to their low concentration,complex matrix,various types and large difference in nature. The key problem to be solved is to develop and study the sample pretreatment system with high efficiency, high throughput and simultaneous adsorption of various antibiotics. On the basis of previous research work,combined with the new angle of solid phase extraction material molecular structure and nano-pore size,this project cooperates with the advantages of diversified building units of salen-COFs,strong adsorption affinity of porosity structure,and so on. A sample pre-treatment system with optimized extraction conditions and functional modification of salen-COFs could be used to efficiently extract various antibiotics at the same time. Based on the pretreatment method system of high throughput and the pretreatment technology of extracting different antibiotics at the same time,combined with liquid chromatography,the method was established for the determination of antibiotic residues in animal foods. It provides an efficient,precise and accurate methodological basis for the analysis and detection of antibiotics in food samples,and further validates the feasibility of the method by analyzing and detecting the kinds and contents of antibiotics in animal foods in the eastern part of China.