由眼外伤、肿瘤等眼病造成的重度眼睑缺损除明显影响外观外，更会导致泪膜异常、眼部刺激症状、眼表炎症、难以治愈的暴露性角膜炎甚至失明。自体或异体材料修补睑板组织，结合手术整复缺损部位皮肤是眼睑重建的首选方法。现有的人工睑板材料生物活性低，力学性能不匹配，局部炎症反应造成睑板腺功能障碍，是眼睑修复、眼表微环境重建亟待解决的难题。因此，本研究拟深入研究睑板组织微纳结构及其与生物力学性能，选取在巨噬细胞M2极化及睑板腺上皮细胞分化通路中均具有重要调控作用的PPARγ作为关键靶点，设计递送PPARγ的可见光交联水凝胶体系，复合高强度熔融电纺PCL支架，创新性构建具有良好机械性能和生物活性的复合支架；阐明复合支架对巨噬细胞M2极化及睑板腺上皮细胞分化、脂质合成的调控机制，探索功能性复合支架在眼睑缺损重建及睑板腺再生修复中的应用，为实现眼睑结构与功能重建的新型睑板支架材料的设计供研究基础。

Ocular trauma and tumor usually cause severe eyelid defects, which relates to significant face appearance change, MGD, abnormal ocular surface, exposure keratitis and visual dysfunction. Tarsal plate substitute and reconstructive surgery is the most effective method for eyelid defects. None of the existing tarsal plate substitutes mimic the special microstructure and biomechanical properties, but cause local inflammatory response and meibomian gland dysfunction. It is a great challenge for eyelid repair and ocular surface microenvironment reconstruction. In this study, microstructure and biomechanical properties of natural tarsal plates are studied. We will design a photopolymerized hydrogel with controlled release of PPARγ, which plays an important role in both the M2 polarization of macrophages and the differentiation of meibomian gland epithelial cells. Then we composite biologically active hydrogel with high strength melt-electrospinning PCL scaffold. The regulation of macrophages M2 polarization and differentiation of mebaromian glandular epithelial cells were evaluated by eyelid defect repair in vivo. We explore the mechanism and repair potential of PPARγ-Gel-PCL scaffold in the repair of eyelid structure and function to lay the foundation for a new tarsal plate substitute and the repair of eyelid regeneration.