基于共轭聚合物的光致电化学传感平台构建及其在农药残留分析中的应用研究

农药残留广泛存在于农产品中，严重危害国家利益、人类健康与社会稳定，探索和发展农药残留分析技术具有重要的理论价值和现实意义。受传感策略与材料性能制约，已报道农药残留检测方法繁琐、稳定性差，在灵敏度、准确度等指标上无法满足农产品中低水平农药残留分析检测的实际需求。为此，本项目拟开展基于共轭聚合物的光致电化学传感平台构建及其在农药残留分析中的应用研究。具体而言，利用有机反应制备兼具电化学聚合与乙酰胆碱酯酶识别能力的单体，采用电化学聚合法构筑共轭聚合物修饰的传感界面。在此基础上，研究共轭聚合物、乙酰胆碱酯酶、农药之间的相互作用，建立构效关系模型，探索识别机理及规律，构筑出具有高输出性能和高稳定性的光致电化学传感平台，为农产品中农药残留的高灵敏、高选择性检测提供新技术与新方法，具有重要的科学研究意义和应用价值，有望获得具有特色的创新性研究成果。

It is of great theoretical and practical importance to explore and develop the sensing strategies for pesticide residues assay due to their influence on national interests, human health, and social stability. Limited by the sensing strategies and the performance of signal sources, previously reported sensors suffered from the tedious process and weak stability, and thus cannot meet the requirement for sensitively and accurately detecting pesticide residues in agricultural products. Thus, in this project, we propose to develop photoelectrochemical (PEC) sensors based on conjugated polymers and to apply them in the analysis of pesticide residues. Monomers that can recognize acetylcholinesterase (AChE) were prepared through organic reactions, and were further employed to fabricate PEC sensing interfaces through electrochemical polymerization technique. The response of conjugated polymers-based PEC sensors to AChE was systemically investigated, and the relationship between molecular structure/aggregation structure of conjugated polymers and analytical performance was also studied. Further, the proposed PEC sensor was employed to detect pesticide residues based on the inhibition of AChE activity by pesticide, providing a high-performance PEC sensor for pesticide residues analysis with strong stability, high sensitivity and good selectivity. Thus, this project is of great scientific importance, and innovative research results are expected.