研究发现，老年人群中痴呆的主要类型AD和VD有着共同的脑血管内皮损伤机制；患者脑微血管内皮细胞膜上介导Aβ转运的LRP-l表达降低及RAGE表达增加，导致血脑屏障Aβ转运机制异常，从而发生Aβ沉积。临床上至今尚无一种能有效抑制Aβ生成和沉积的治疗痴呆方法，而从患者脑中清除Aβ则成为新的研究热点。痴呆的中医病机为本虚标实，本虚为肾精亏损和气血不足，标实为痰浊阻窍和气滞血瘀，目前对AD和VD都有临床疗效的经方当归芍药散则具有补本虚、祛标实特点。本课题从当归芍药散改善痴呆动物脑微血管内皮细胞功能障碍及调节血脑屏障Aβ转运机制入手，用APP/PS1转基因小鼠和结扎大鼠双侧颈总动脉分别模拟AD和VD的病理和学习记忆行为学特征，并用糖氧剥夺的脑微血管内皮细胞作为培养材料，从体内和体外实验两方面探讨当归芍药散及拆方（活血养血药和健脾利湿药）治疗AD和VD的共同作用机制，为其临床应用提供新的实验依据。

According to recent study, dysfunction of brain vascular endothelial cells may be the common cause of both AD (Alzheimer's Disease) and VD (Vascular Dementia) in the elderly population. Abnormal expression of Amyloid-β receptors which mediate Aβ transport from the brain to the blood may result in Aβ accumulation and aggregation, such as a reduction of LRP-1 expression and an overexpression of RAGE in the brain microvascular endothelial cells (BMEC). So far, there is still no effective medicine to reduce the production of Aβ or prevent it from accumulation. So looking for a new therapy to improve the transport of Aβ becomes popular. The pathogenesis of Chinese medicine for the dementia was considered as "deficiency in origin and excess in superficiality". "Deficiency in origin" means kidney essence deficiency and insufficiency of Qi-Blood, while "Excess in superficiality" means phlegm retention in head and Qi Blood stasis. The Danggui-Shaoyao-San（DSS,the Chinese medicine） has effects on "reinforce insufficiency and reduce excessiveness". Preceding studies indicated its effects on both AD and VD. Our study aims to investigate the effects of DSS and its decomposed recipes on improving the function of BMEC on dementia animal model and the mechanism on Aβ transport across blood brain barrier. To imitate AD and VD animal model, the APP/PS1 transgenic mice and the models of rats caused by ligation of bilateral commoncarotid arteries were used, while cultured BMEC in an oxygen deficit condition was also employed. We hope to provide some new evidences of DSS in treatment with AD and VD.