基于焦谷氨酸手性识别模块功能化纳米材料的两相分散固相萃取手性拆分研究

手性萃取拆分具有设备简单、操作条件温和、适合连续操作及大规模生产应用等优点，是目前获得光学纯手性分子的主要方法之一，而高立体选择性手性拆分剂是手性萃取拆分成功的关键。项目基于“三点作用理论”，以具有优异氢键结合和立体控制能力的焦谷氨酸为基体，通过衍生设计合成具有高立体选择性的手性识别模块，基于第一性原理及手性荧光分析评估其手性识别能力；设计制备亲脂性/亲水性单分散介孔纳米材料，完成手性识别模块(D/L型)的功能化修饰，以此建立双向协同识别两相分散固相萃取手性拆分体系；利用全因子试验结合响应表面法对萃取实验参数进行优化，实现手性对映体的高效萃取拆分；并尝试与多级萃取技术联用，建立相应的传质数学模型，实现单一构型手性对映体的纯化分离。本研究将化工分离工程、有机合成、功能材料化学和分析化学多学科知识有效融合，将为手性拆分剂设计及手性萃取拆分提供新思路，有助于促进化工分离新技术的探索与发展。

As one of the major approaches to obtaining optically pure chiral molecules, chiral extraction separation has demonstrated several advantages such as simple equipment, mild operational conditions, suitable for continuous operation and large-scale production. And the key factor for the success of chiral extraction separation is the screening of chiral resolving agents with high stereoselectivity. In this proposal, based on the "three-point interaction rule", chiral recognition modules with high stereoselectivity will be designed and synthesized by derivatizing the parent molecule pyroglutamic acid (PGlu) which possesses excellent capabilities in hydrogen-bond binding and stereocontrol. The chiral recognition capability of the developed chiral recognition modules will be evaluated via the first principles calculation and chiral fluorescence analysis. Lipophilic/hydrophilic monodisperse mesoporous nanomaterials (MMNs) will be fabricated and modified with chiral recognition modules (D/L), and chiral separation systems with bidirectional collaborative recognition by virtue of two-phase dispersion solid-phase extraction (d-SPE) will be developed by employing the functionalized MMNs as the chiral resolving agents. To realize highly efficient extraction enantioseparation, the experimental parameters will be comprehensively optimized by combining full factorial design and response surface method. The optimized chiral separation systems will be integrated with multistage extraction techniques, and the corresponding mass transfer mathematical model will also be established to achieve successful purification and separation for single enantiomer. The whole research work would effectively integrate multi-disciplines, including chemical separation engineering, organic synthesis, functional material chemistry as well as analytical chemistry, and provide new perspectives for the extraction enantioseparation and the design of chiral resolving agents, thus promoting and facilitating the exploration and development of novel chemical separation technologies.