溶剂气浮是一种在工业生产中应用广泛的分离技术，具有设备简单、成本低廉、能耗小、分离效率高等优点。本项目将其引入手性拆分领域，提出了一种溶剂气浮手性拆分药物对映体的新技术：借助鼓泡使药物对映体在水相和有机相间进行质量传递，水相和有机相中至少有一相含有手性选择剂，这些手性选择剂依靠包结复合、氢键等作用力与药物对映体发生相互作用，对不同光学构型的对映单体而言，这种相互作用力的大小存在差异，从而依靠这种差异来实现药物对映体的手性拆分。本项目首先研究手性选择剂的性质、筛选及合成，确立三类高效的溶剂气浮手性拆分体系，再考察溶剂气浮手性拆分的优化工艺条件，最后探讨此分离过程的相关机理，建立溶剂气浮手性拆分的传质数学模型，研究溶剂气浮装置的放大效应。经初步研究表明，相比于其他手性拆分技术，该技术具有高效的手性拆分性能和良好的应用前景。本课题的完成在理论和方法上将有新的突破，有助于新型手性拆分技术的探索。

As a separation technology, solvent sublation has been widely used in industrial production with some advantages including simple equipment, low cost and energy consumption, and high separating efficiency etc. In this project, solvent sublation, as a new technology for the resolution, is introduced in chiral separation of drug enantiomers for the first time. Generally, in the separation process,the mass transfer of drug enantiomers between aqueous phase and organic phase is conducted and strengthened by bubbles. Meanwhile, chiral selectors exist in either of the two phases, which interact with drug enantiomers through hydrogen-bonding, inclusion and steric effect etc. For different optical enantiomers of a given drug,the interaction forces are different, depending on which solvent sublation can be used for conducting drug enantioseparation. In this project,the properties, synthesis and screening of chiral selectors will be studied for the first time, and three kinds of efficient solvent sublation systems will be established. Therefore, the process conditions of drug enantioseparation by solvent sublation can be optimized. Furthermore, the relevant mechanism in this separation process will be investigated, a general mathematical model of mass transfer for the chiral resolution by solvent sublation will be established and the magnifying effect of solvent sublation apparatus will aslo be studied. Our preliminary studies showed that compared with other enantioseparation technologies, solvent sublation has higher separating efficiency and broader application foreground. The completion of this project is expected to make a breakthrough in both theory and method aspects, which will significantly contribute to the exploration of new technologies for chiral resolution.