基于中国人群偏好的生命质量研究- - 构建EQ-5D量表效用积分体系

EQ-5D量表是英国健康与临床优化研究所(NICE)推荐用于成本效用分析最主要的健康测量工具，也是国际上使用最为广泛的通用量表之一。与量表配套使用的效用积分体系与各地的文化背景紧密相连，但由于EQ-5D量表缺乏以中国人群偏好为基础建立的积分体系，现有采用其他国家体系所计算的健康状态效用值不能科学用于开展中国的成本效用分析和相关决策评估。本课题拟采用时间权衡法(TTO)对大规模中国人群进行调研，并使用计量经济学方法估计预测模型，构建适合于中国人群的EQ-5D量表效用积分体系。本课题的研究成果将有利于推动成本效用分析在中国的应用与发展，同时也将为其他量表的积分体系建立提供良好的实证研究经验，这对更好地促进在中国医疗卫生体制改革中具有关键作用的卫生技术评估长远发展具有重要意义。

EQ-5D instrument is recommended by National Institute for Health and Clinical Excellence (NICE) in UK for cost-utility analysis (CUA). It is also widely used as a generic instrument across the world. The social value set coupled with the instrument is closely related to different cultural background. Without a value set based on Chinese population, the current applications of EQ-5D in China based on preferences from other countries cannot scientifically guide the health care prioritizations and policy-makings. This research uses time trade-off (TTO) method to elicit preferences from large sample surveys in China, and uses econometric models to estimate and finally establish the EQ-5D value set for China. The results obtained from this research will promote the development of CUA in particular and health technology assessment (HTA) in general for Chinese population, which plays a vital role in the health care system reform in China.