犬细小病毒（Canine Parvovirus，CPV）病是威胁犬只健康的重要急性传染病。然而，现有措施对该病的治疗作用仍然有限。因此，新的抗病毒治疗方法亟待探索和开发。犬干扰素-β（Canine interferon-β, CaIFN-β）是重要的I型IFN，其抗病毒效应尚无报道，CPV与CaIFN-β的互作关系也尚未阐明。我们的前期研究发现CPV可激活犬IFN-β应答，从而推断CPV的特定病毒蛋白与IFN-β应答通路之间存在互作关系。因此，本项目拟通过研究CaIFN-β抑制CPV复制的抗病毒效应；探索CPV通过何种信号通路以何种方式激活犬IFN-β应答；筛选发挥激活IFN-β应答作用的CPV病毒成分，并进一步筛选和验证与该病毒蛋白互作的宿主蛋白，从而探索CPV激活犬IFN-β应答的分子机制。该研究为解析CaIFN-β的抗病毒效应、阐明CPV的致病机制和寻找CPV病的防治新靶点提供基础。

Canine parvovirus (CPV) disease is an important infectious disease threatening the health of dogs. However, currently available treatments are still limited to this disease. Hence, the development of a novel treatment is in need urgently. Canine interferon-β (CaIFN-β) is one of the important type I IFN. However, the understanding of CaIFN-β antiviral effects is limited. Moreover, the association between CPV and CaIFN-β is still in mysterious. Our previous works found that the CPV replication can activate the CaIFN-β response. Based on this finding, we inferred that viral proteins of CPV associate with the CaIFN-β response. For this project, we aim to analyse the antiviral effects of CaIFN-β on the CPV replication. And，we can explore how CPV activate the CaIFN-β response via which signalling pathway. Moreover, we will export which viral protein can activate the IFN-β response. Furthermore, we will identify which host proteins can interact with the viral protein and export the mechanism of how CPV activate the CaIFN-β response. This project will lay the foundations for analysing the antiviral effect of the CaIFN-β, elucidating the pathogenesis of CPV, and finding the prevention and treatment new targets of CPV disease.