Hyperdopaminergic tone in HIV-1 protein treated rats and cocaine sensitization.
Hyperdopaminergic tone in HIV-1 protein treated rats and cocaine sensitization.
复制标题
HIV-1 蛋白治疗大鼠的多巴胺能亢进和可卡因致敏。
DOI：
10.1111/j.1471-4159.2010.06968.x
复制
发表时间：
2010-11
影响因子：
4.7
通讯作者：
Booze RM
中科院分区：
文献类型：
--
作者：
Ferris MJ;Frederick-Duus D;Fadel J;Mactutus CF;Booze RM
在美国，三分之一的感染者通过用受污染的针头注射毒品或通过与吸毒有关的危险行为感染了人类免疫缺陷病毒-1（HIV-1）。研究表明，同时服用精神兴奋剂和HIV-1蛋白质比单独使用病毒蛋白质或药物更能损害神经元。为了模拟HIV-1感染与药物使用史的关系，目前的研究比较了在有和没有可卡因（Coc）经历史的动物中输注Tat 1 -86后的行为和细胞外多巴胺和代谢物水平（10 mg/kg; i. p.; 1次注射/天× 9天）。接受Coc行为敏化方案的动物表现出丘脑核中细胞外多巴胺浓度的降低，与描述多巴胺转运蛋白摄取上调的证据一致。与此效应相反，Tat 1 -86微输注到致敏方案的Coc后，在48小时内引起细胞外多巴胺水平（nM）的显着增加，与基线响应的百分比没有差异。72小时后，达特+ Coc处理的动物表现出对钾刺激的细胞外多巴胺释放的钝化作用（基线的百分比），对Coc激发的行为敏化的表达相应降低。在Tat治疗的动物中，在所有时间点均发现细胞外多巴胺代谢物水平持续降低，与Coc的经验无关。目前的研究提供了证据，不同的神经化学和行为的结果后，Tat治疗，根据经验与COC。
In the United States, one-third of infected individuals contracted Human Immunodeficiency Virus-1 (HIV-1) via injecting drugs with contaminated needles or through risky behaviors associated with drug use. Research demonstrates concomitant administration of psychostimulants and HIV-1-proteins damage neurons to a greater extent than viral proteins or the drug alone. To model the onset of HIV-1-infection in relation to a history of drug use, the current research compared behavior and extracellular dopamine and metabolite levels following Tat1–86 infusions in animals with and without a history of cocaine (Coc) experience (10 mg/kg; i.p.; 1 injection/day × 9 days). Animals receiving a behaviorally sensitizing regimen of Coc demonstrated a decrease in extracellular dopamine concentration in the nucleus accumbens, consistent with evidence describing up-regulation of dopamine transporter uptake. Contrary to this effect, Tat1–86 microinfusion into the nucleus accumbens following the sensitizing regimen of Coc caused a significant increase in extracellular dopamine levels (nM) within 48 h with no difference in percent of baseline response to Coc. After 72 h, Tat + Coc treated animals demonstrated a blunted effect on potassium-stimulated extracellular dopamine release (percent of baseline) with a corresponding decrease in expression of behavioral sensitization to Coc challenge. A persistent decrease in extracellular dopamine metabolite levels was found across all time-points in Tat-treated animals, regardless of experience with Coc. The current study provides evidence for divergent neurochemical and behavioral outcomes following Tat-treatment; contingent upon experience with Coc.
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影响因子：
4.2
作者：
Crits-Christoph, Paul;Newberg, Andrew;Present, Julie
通讯作者：
Present, Julie
影响因子：
5.7
作者：
Chang, Linda;Wang, Gene-Jack;Fowler, Joanna S.
通讯作者：
Fowler, Joanna S.
影响因子：
3.4
作者：
Lack, Christopher M.;Jones, Sara R.;Roberts, David C. S.
通讯作者：
Roberts, David C. S.
影响因子：
3.6
作者：
Harrod, S. B.;Mactutus, C. F.;Booze, R. M.
通讯作者：
Booze, R. M.
影响因子：
3.3
作者：
Ferris, M. J.;Frederick-Duus, D.;Fadel, J.;Mactutus, C. F.;Booze, R. M.
通讯作者：
Booze, R. M.